malariagen_data.ag3.Ag3.plot_roh

Ag3.plot_roh(sample: str | int, region: str | Region | Mapping, window_size: int = 20000, site_mask: str | None = 'default', sample_set: str | None = None, phet_roh: float = 0.001, phet_nonroh: Tuple[float, ...] = (0.003, 0.01), transition: float = 0.001, y_max: float = 0.03, sizing_mode: Literal['fixed', 'stretch_width', 'stretch_height', 'stretch_both', 'scale_width', 'scale_height', 'scale_both'] = 'stretch_width', width: int | None = None, heterozygosity_height: int = 170, roh_height: int = 40, genes_height: int = 90, circle_kwargs: Mapping | None = None, show: bool = True, output_backend: Literal['canvas', 'webgl', 'svg'] = 'webgl', chunks: int | str | Tuple[int | str, ...] | Callable[[Tuple[int, ...]], int | str | Tuple[int | str, ...]] = 'native', inline_array: bool = True, gene_labels: Mapping[str, str] | None = None, gene_labelset: LabelSet | None = None) → Model | None

Plot windowed heterozygosity and inferred runs of homozygosity for a single sample over a genome region.

Parameters

samplestr or int

Sample identifier or index within sample set.

regionstr or Region or Mapping

Region of the reference genome. Can be a contig name, region string (formatted like “{contig}:{start}-{end}”), or identifier of a genome feature such as a gene or transcript.

window_sizeint, optional, default: 20000

Number of sites per window.

site_maskstr or None, optional, default: ‘default’

Which site filters mask to apply. See the site_mask_ids property for available values.

sample_setstr or None, optional

Sample set identifier.

phet_rohfloat, optional, default: 0.001

Probability of observing a heterozygote in a ROH.

phet_nonrohtuple of float, optional, default: (0.003, 0.01)

One or more probabilities of observing a heterozygote outside a ROH.

transitionfloat, optional, default: 0.001

Probability of moving between states. A larger window size may call for a larger transitional probability.

y_maxfloat, optional, default: 0.03

Y axis limit.

sizing_mode{‘fixed’, ‘stretch_width’, ‘stretch_height’, ‘stretch_both’, ‘scale_width’, ‘scale_height’, ‘scale_both’}, optional, default: ‘stretch_width’

Bokeh plot sizing mode, see also https://docs.bokeh.org/en/latest/docs /user_guide/basic/layouts.html#sizing-modes.

widthint or None, optional

Plot width in pixels (px).

heterozygosity_heightint, optional, default: 170

Plot height in pixels (px).

roh_heightint, optional, default: 40

Plot height in pixels (px).

genes_heightint, optional, default: 90

Genes track height in pixels (px).

circle_kwargsMapping or None, optional

Passed through to bokeh scatter() function with marker = ‘circle’.

showbool, optional, default: True

If true, show the plot. If False, do not show the plot, but return the figure.

output_backend{‘canvas’, ‘webgl’, ‘svg’}, optional, default: ‘webgl’

Specify an output backend to render a plot area onto. See also https://docs.bokeh.org/en/latest/docs/user_guide/output/webgl.html.

chunksint or str or tuple of int or str or Callable[[typing.Tuple[int, …]], int or str or tuple of int or str], optional, default: ‘native’

Define how input data being read from zarr should be divided into chunks for a dask computation. If ‘native’, use underlying zarr chunks. If a string specifying a target memory size, e.g., ‘300 MiB’, resize chunks in arrays with more than one dimension to match this size. If ‘auto’, let dask decide chunk size. If ‘ndauto’, let dask decide chunk size but only for arrays with more than one dimension. If ‘ndauto0’, as ‘ndauto’ but only vary the first chunk dimension. If ‘ndauto1’, as ‘ndauto’ but only vary the second chunk dimension. If ‘ndauto01’, as ‘ndauto’ but only vary the first and second chunk dimensions. Also, can be a tuple of integers, or a callable which accepts the native chunks as a single argument and returns a valid dask chunks value.

inline_arraybool, optional, default: True

Passed through to dask from_array().

gene_labelsMapping[str, str] or None, optional

A mapping of gene identifiers to custom labels, which will appear in the plot.

gene_labelsetLabelSet or None, optional

A LabelSet to use in the plot.

Returns

Model or None

A bokeh figure (only returned if show=False).