H12 / Angola An. coluzzii / Chromosome 2 / #5

This page describes a signal of selection found in the Angola An. coluzzii population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 59,700,001 and 60,240,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 5 genes overlap the focal region: AGAP004659 (Homeotic antennapedia protein), AGAP013157 (Antp family), AGAP004660 (Antennapedia homeotic protein), AGAP004661 (Antp family, other), AGAP004662 (homeobox protein abdominal-A homolog).

No genes are within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 82
    # data points      = 235
    # variables        = 3
    chi-square         = 0.833
    reduced chi-square = 0.004
    Akaike info crit   = -1319.942
    Bayesian info crit = -1309.564
[[Variables]]
    amplitude:   0.33070797 +/- 0.016384 (4.95%) (init= 0.5)
    decay:       2.99999974 +/- 0.317671 (10.59%) (init= 0.5)
    c:           0.05999999 +/- 0.037655 (62.76%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  =  0.927
    C(amplitude, c)              =  0.833
    C(amplitude, decay)          =  0.647

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 113
    # data points      = 329
    # variables        = 3
    chi-square         = 2.752
    reduced chi-square = 0.008
    Akaike info crit   = -1567.850
    Bayesian info crit = -1556.461
[[Variables]]
    amplitude:   0.27637999 +/- 0.020414 (7.39%) (init= 0.5)
    decay:       3          +/- 0.065861 (2.20%) (init= 0.5)
    c:           0.05999999 +/- 0.193846 (323.08%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  =  0.909
    C(amplitude, c)              =  0.752
    C(amplitude, decay)          =  0.487

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 233
    # variables        = 1
    chi-square         = 2.793
    reduced chi-square = 0.012
    Akaike info crit   = -1028.740
    Bayesian info crit = -1025.289
[[Variables]]
    c:   0.21034692 +/- 0.007188 (3.42%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 328
    # variables        = 1
    chi-square         = 3.053
    reduced chi-square = 0.009
    Akaike info crit   = -1532.009
    Bayesian info crit = -1528.216
[[Variables]]
    c:   0.20468030 +/- 0.005335 (2.61%) (init= 0.03)

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