H12 / Angola An. coluzzii / Chromosome 2 / #7

This page describes a signal of selection found in the Angola An. coluzzii population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 48,180,001 and 48,240,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP013324 (putative G-protein coupled receptor GPCR) overlaps the focal region.

The following 5 genes are within 50 kbp of the focal region: AGAP004033, AGAP004034 (GPRNNA4 - putative GPCR class a orphan receptor 4), AGAP004035 (GPRFSH - putative glyco-protein hormone fsh-like receptor), AGAP0040361 (HPX7 - heme peroxidase 7), AGAP0040381 (HPX8 - heme peroxidase 8).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 23
    # data points      = 189
    # variables        = 3
    chi-square         = 0.071
    reduced chi-square = 0.000
    Akaike info crit   = -1484.757
    Bayesian info crit = -1475.032
[[Variables]]
    amplitude:   0.11826571 +/- 0.013634 (11.53%) (init= 0.5)
    decay:       0.24242724 +/- 0.045613 (18.82%) (init= 0.5)
    c:           0.04565794 +/- 0.001517 (3.32%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.616
    C(decay, c)                  = -0.258

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 27
    # data points      = 195
    # variables        = 3
    chi-square         = 0.107
    reduced chi-square = 0.001
    Akaike info crit   = -1458.453
    Bayesian info crit = -1448.634
[[Variables]]
    amplitude:   0.06820723 +/- 0.012300 (18.03%) (init= 0.5)
    decay:       0.66659540 +/- 0.184209 (27.63%) (init= 0.5)
    c:           0.05551112 +/- 0.002069 (3.73%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.660
    C(decay, c)                  = -0.445

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 188
    # variables        = 1
    chi-square         = 0.107
    reduced chi-square = 0.001
    Akaike info crit   = -1403.071
    Bayesian info crit = -1399.834
[[Variables]]
    c:   0.04910978 +/- 0.001742 (3.55%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 194
    # variables        = 1
    chi-square         = 0.124
    reduced chi-square = 0.001
    Akaike info crit   = -1425.089
    Bayesian info crit = -1421.821
[[Variables]]
    c:   0.06056056 +/- 0.001819 (3.00%) (init= 0.03)

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