H12 / Angola An. coluzzii / Chromosome 3 / #2

This page describes a signal of selection found in the Angola An. coluzzii population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 41,920,001 and 42,180,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 16 genes overlap the focal region: AGAP009733 (wingless-type MMTV integration site family, member 6), AGAP009734 (wingless-type MMTV integration site family, member 1), AGAP009735 (wingless-type MMTV integration site family, member 16), AGAP009736 (solute carrier family 4 member 10), AGAP009737 (Elongation factor G, mitochondrial), AGAP0097381 (GRX3 - glutaredoxin), AGAP009739 (vacuolar protein sorting 52 homolog), AGAP009740 (tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase), AGAP009741, AGAP009742 (splicing factor, arginine/serine-rich 2), AGAP009743 (ribonuclease Z), AGAP009744, AGAP009745 (Sugar transporter ERD6-like 4), AGAP009746 (RuvB-like protein 2), AGAP009747 (gamma-interferon-inducible lysosomal thiol reductase precursor), AGAP028645 (aryl hydrocarbon receptor nuclear translocator).

Gene AGAP009732 (Protein Wnt) is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Gabon An. gambiae / Chromosome 3 / #3 3R:41,840,001-41,960,000 158 (30 | 128)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 67
    # data points      = 294
    # variables        = 3
    chi-square         = 0.046
    reduced chi-square = 0.000
    Akaike info crit   = -2569.190
    Bayesian info crit = -2558.139
[[Variables]]
    amplitude:   0.07692110 +/- 0.007298 (9.49%) (init= 0.5)
    decay:       0.28398721 +/- 0.032060 (11.29%) (init= 0.5)
    c:           0.02463415 +/- 0.000892 (3.62%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.723
    C(decay, c)                  = -0.426

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 37
    # data points      = 194
    # variables        = 3
    chi-square         = 0.071
    reduced chi-square = 0.000
    Akaike info crit   = -1530.141
    Bayesian info crit = -1520.337
[[Variables]]
    amplitude:   0.06427053 +/- 0.017452 (27.16%) (init= 0.5)
    decay:       0.26670192 +/- 0.098347 (36.88%) (init= 0.5)
    c:           0.05399816 +/- 0.001486 (2.75%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.737
    C(decay, c)                  = -0.271

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 293
    # variables        = 1
    chi-square         = 0.078
    reduced chi-square = 0.000
    Akaike info crit   = -2407.899
    Bayesian info crit = -2404.218
[[Variables]]
    c:   0.02949232 +/- 0.000958 (3.25%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 193
    # variables        = 1
    chi-square         = 0.077
    reduced chi-square = 0.000
    Akaike info crit   = -1508.435
    Bayesian info crit = -1505.172
[[Variables]]
    c:   0.05569574 +/- 0.001441 (2.59%) (init= 0.03)

Comments