H12 / Burkina Faso An. gambiae / Chromosome 2 / #4

This page describes a signal of selection found in the Burkina Faso An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 3,400,001 and 3,480,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 6 genes overlap the focal region: AGAP001350, AGAP001351, AGAP001352, AGAP0013533, AGAP0013543, AGAP0013553.

The following 9 genes are within 50 kbp of the focal region: AGAP001344, AGAP001345 (hexamerin), AGAP001346, AGAP001347, AGAP001348, AGAP001349 (chronic lymphocytic leukemia deletion region gene 6 protein-like protein), AGAP0013561 (ACE1 - Acetylcholinesterase), AGAP001357 (beta-catenin-like protein 1), AGAP001358.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Guinea An. gambiae / Chromosome 2 / #5 2R:3,400,001-3,460,000 179 (142 | 37)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 27
    # data points      = 148
    # variables        = 3
    chi-square         = 0.003
    reduced chi-square = 0.000
    Akaike info crit   = -1590.501
    Bayesian info crit = -1581.510
[[Variables]]
    amplitude:   0.05691908 +/- 0.002520 (4.43%) (init= 0.5)
    decay:       0.44727876 +/- 0.033086 (7.40%) (init= 0.5)
    c:           0.01265460 +/- 0.000449 (3.55%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.579
    C(decay, c)                  = -0.422

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 83
    # data points      = 150
    # variables        = 3
    chi-square         = 0.004
    reduced chi-square = 0.000
    Akaike info crit   = -1571.773
    Bayesian info crit = -1562.741
[[Variables]]
    amplitude:   0.03350765 +/- 0.002187 (6.53%) (init= 0.5)
    decay:       1.00065551 +/- 0.124233 (12.42%) (init= 0.5)
    c:           0.01081279 +/- 0.000719 (6.66%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.684
    C(amplitude, decay)          = -0.531

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 147
    # variables        = 1
    chi-square         = 0.015
    reduced chi-square = 0.000
    Akaike info crit   = -1346.308
    Bayesian info crit = -1343.317
[[Variables]]
    c:   0.01642202 +/- 0.000844 (5.14%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 149
    # variables        = 1
    chi-square         = 0.012
    reduced chi-square = 0.000
    Akaike info crit   = -1402.859
    Bayesian info crit = -1399.855
[[Variables]]
    c:   0.01605582 +/- 0.000737 (4.59%) (init= 0.03)

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