H12 / Burkina Faso An. gambiae / Chromosome 2 / #8

This page describes a signal of selection found in the Burkina Faso An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 42,300,001 and 42,380,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP0070862 (Sodium channel protein) overlaps the focal region.

The following 8 genes are within 50 kbp of the focal region: AGAP007081, AGAP0070821 (NADH dehydrogenase (ubiquinone) Fe-S protein 4), AGAP007083, AGAP007084, AGAP007085, AGAP007087 (RpL41 - 60s ribosomal protein L41), AGAP007088 (peptidyl-prolyl cis-trans isomerase B (cyclophilin B)), AGAP007089.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 43
    # data points      = 150
    # variables        = 3
    chi-square         = 0.004
    reduced chi-square = 0.000
    Akaike info crit   = -1561.576
    Bayesian info crit = -1552.544
[[Variables]]
    amplitude:   0.02565956 +/- 0.004404 (17.17%) (init= 0.5)
    decay:       0.15000022 +/- 0.042462 (28.31%) (init= 0.5)
    c:           0.01371870 +/- 0.000468 (3.41%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.581
    C(decay, c)                  = -0.230

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 31
    # data points      = 149
    # variables        = 3
    chi-square         = 0.001
    reduced chi-square = 0.000
    Akaike info crit   = -1748.198
    Bayesian info crit = -1739.186
[[Variables]]
    amplitude:   0.03161851 +/- 0.002118 (6.70%) (init= 0.5)
    decay:       0.35489336 +/- 0.034119 (9.61%) (init= 0.5)
    c:           0.01113040 +/- 0.000263 (2.37%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.705
    C(decay, c)                  = -0.368

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 149
    # variables        = 1
    chi-square         = 0.005
    reduced chi-square = 0.000
    Akaike info crit   = -1532.440
    Bayesian info crit = -1529.436
[[Variables]]
    c:   0.01425650 +/- 0.000477 (3.35%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 148
    # variables        = 1
    chi-square         = 0.004
    reduced chi-square = 0.000
    Akaike info crit   = -1555.782
    Bayesian info crit = -1552.785
[[Variables]]
    c:   0.01273623 +/- 0.000427 (3.36%) (init= 0.03)

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