H12 / Burkina Faso An. gambiae / Chromosome 3 / #2

This page describes a signal of selection found in the Burkina Faso An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 26,880,001 and 26,920,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 6 genes overlap the focal region: AGAP011532 (septin), AGAP011533 (tetratricopeptide repeat protein 15), AGAP011534, AGAP011535 (transcription elongation factor B, polypeptide 1), AGAP011536 (Mini-chromosome maintenance complex-binding protein), AGAP011537 (Argonaute 3).

The following 7 genes are within 50 kbp of the focal region: AGAP011530, AGAP011531 (Selenium-binding protein 2), AGAP028430, AGAP011538, AGAP011539 (dynein intermediate chain 2, axonemal), AGAP011540 (dynein intermediate chain 2, axonemal), AGAP011541 (Ecto-NOX disulfide-thiol exchanger 1).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Cameroon An. gambiae / Chromosome 3 / #2 3L:26,880,001-26,940,000 294 (265 | 29)
H12 / Guinea An. gambiae / Chromosome 3 / #3 3L:26,860,001-26,900,000 171 (77 | 93)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 44
    # data points      = 149
    # variables        = 3
    chi-square         = 0.003
    reduced chi-square = 0.000
    Akaike info crit   = -1627.698
    Bayesian info crit = -1618.687
[[Variables]]
    amplitude:   0.07138020 +/- 0.003405 (4.77%) (init= 0.5)
    decay:       0.15000000 +/- 0.012124 (8.08%) (init= 0.5)
    c:           0.01015940 +/- 0.000363 (3.57%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.581
    C(decay, c)                  = -0.231

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 39
    # data points      = 150
    # variables        = 3
    chi-square         = 0.008
    reduced chi-square = 0.000
    Akaike info crit   = -1473.916
    Bayesian info crit = -1464.884
[[Variables]]
    amplitude:   0.07182790 +/- 0.008340 (11.61%) (init= 0.5)
    decay:       0.19100194 +/- 0.029139 (15.26%) (init= 0.5)
    c:           0.00937114 +/- 0.000636 (6.79%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.759
    C(decay, c)                  = -0.261

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 148
    # variables        = 1
    chi-square         = 0.010
    reduced chi-square = 0.000
    Akaike info crit   = -1416.847
    Bayesian info crit = -1413.850
[[Variables]]
    c:   0.01177360 +/- 0.000683 (5.80%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 149
    # variables        = 1
    chi-square         = 0.010
    reduced chi-square = 0.000
    Akaike info crit   = -1432.369
    Bayesian info crit = -1429.365
[[Variables]]
    c:   0.01085732 +/- 0.000668 (6.15%) (init= 0.03)

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