H12 / Burkina Faso An. gambiae / Chromosome 3 / #5

This page describes a signal of selection found in the Burkina Faso An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 43,640,001 and 43,680,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 7 genes overlap the focal region: AGAP009799 (ABCC13 - ATP-binding cassette transporter (ABC transporter) family C member 13), AGAP009800, AGAP009801, AGAP0098023 (Gr12 - gustatory receptor 12), AGAP0098033 (Gr11 - gustatory receptor 11), AGAP0098043 (Gr10 - gustatory receptor 10), AGAP0098053 (Gr9 - gustatory receptor 9).

The following 4 genes are within 50 kbp of the focal region: AGAP009806 (MAX-like protein X), AGAP009807 (E2F transcription factor 4/5), AGAP009808 (ATP-dependent RNA helicase DDX47/RRP3), AGAP009809.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 44
    # data points      = 239
    # variables        = 3
    chi-square         = 0.144
    reduced chi-square = 0.001
    Akaike info crit   = -1766.714
    Bayesian info crit = -1756.285
[[Variables]]
    amplitude:   0.06203460 +/- 0.007215 (11.63%) (init= 0.5)
    decay:       1.99999908 +/- 0.748801 (37.44%) (init= 0.5)
    c:           0.03239854 +/- 0.006633 (20.48%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.936
    C(amplitude, c)              = -0.348
    C(amplitude, decay)          =  0.101

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 37
    # data points      = 148
    # variables        = 3
    chi-square         = 0.057
    reduced chi-square = 0.000
    Akaike info crit   = -1157.863
    Bayesian info crit = -1148.871
[[Variables]]
    amplitude:   0.15957289 +/- 0.027369 (17.15%) (init= 0.5)
    decay:       0.15000000 +/- 0.001981 (1.32%) (init= 0.5)
    c:           0.04751270 +/- 0.001718 (3.62%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          =  0.782
    C(decay, c)                  =  0.232

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 238
    # variables        = 1
    chi-square         = 0.173
    reduced chi-square = 0.001
    Akaike info crit   = -1718.313
    Bayesian info crit = -1714.841
[[Variables]]
    c:   0.04649386 +/- 0.001750 (3.76%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 147
    # variables        = 1
    chi-square         = 0.070
    reduced chi-square = 0.000
    Akaike info crit   = -1121.802
    Bayesian info crit = -1118.812
[[Variables]]
    c:   0.05006184 +/- 0.001810 (3.62%) (init= 0.03)

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