H12 / Burkina Faso An. gambiae / Chromosome X / #3

This page describes a signal of selection found in the Burkina Faso An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 9,640,001 and 9,720,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 4 genes overlap the focal region: AGAP000539, AGAP000540 (proton-coupled amino acid transporter), AGAP000541 (RpS15a-1 - 40S ribosomal protein S15a), AGAP013055.

The following 7 genes are within 50 kbp of the focal region: AGAP000535, AGAP028592, AGAP012976, AGAP013521, AGAP000536 (PGRPS1 - peptidoglycan recognition protein (short)), AGAP000537 (TWDL8 - cuticular protein TWDL family (TWDL8)), AGAP000538 (TWDL9 - cuticular protein TWDL family (TWDL9)).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 35
    # data points      = 151
    # variables        = 3
    chi-square         = 0.032
    reduced chi-square = 0.000
    Akaike info crit   = -1272.262
    Bayesian info crit = -1263.210
[[Variables]]
    amplitude:   0.06460198 +/- 0.011786 (18.25%) (init= 0.5)
    decay:       0.15435250 +/- 0.045938 (29.76%) (init= 0.5)
    c:           0.02036912 +/- 0.001259 (6.18%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.584
    C(decay, c)                  = -0.233

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 27
    # data points      = 149
    # variables        = 3
    chi-square         = 0.003
    reduced chi-square = 0.000
    Akaike info crit   = -1595.473
    Bayesian info crit = -1586.461
[[Variables]]
    amplitude:   0.07966178 +/- 0.003243 (4.07%) (init= 0.5)
    decay:       0.40856456 +/- 0.024394 (5.97%) (init= 0.5)
    c:           0.01702704 +/- 0.000450 (2.64%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.691
    C(decay, c)                  = -0.399

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 150
    # variables        = 1
    chi-square         = 0.036
    reduced chi-square = 0.000
    Akaike info crit   = -1247.831
    Bayesian info crit = -1244.821
[[Variables]]
    c:   0.02175038 +/- 0.001270 (5.84%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 148
    # variables        = 1
    chi-square         = 0.025
    reduced chi-square = 0.000
    Akaike info crit   = -1285.253
    Bayesian info crit = -1282.256
[[Variables]]
    c:   0.02180952 +/- 0.001065 (4.89%) (init= 0.03)

Comments