H12 / Gabon An. gambiae / Chromosome 2 / #1

This page describes a signal of selection found in the Gabon An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 25,460,001 and 25,520,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 7 genes overlap the focal region: AGAP006030 (mfrn - mitoferrin), AGAP006031 (nuclear pore complex protein Nup54), AGAP006032, AGAP006033, AGAP006034, AGAP006035 (Ras-related protein Rab-36), AGAP006036 (axonemal dynein intermediate chain inner arm i1).

The following 9 genes are within 50 kbp of the focal region: AGAP0060282 (Rdl - GABA-gated chloride channel subunit), AGAP006029, AGAP006037 (RpL24 - 60S ribosomal protein L24), AGAP006038 (serine/arginine repetitive matrix protein 2), AGAP006039, AGAP006040 (peroxisomal membrane protein 2), AGAP006041 (E3 ubiquitin-protein ligase RNF5), AGAP006042, AGAP029130.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Burkina Faso An. coluzzii / Chromosome 2 / #2 2L:25,400,001-25,520,000 919 (426 | 492)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 53
    # data points      = 151
    # variables        = 3
    chi-square         = 0.161
    reduced chi-square = 0.001
    Akaike info crit   = -1027.551
    Bayesian info crit = -1018.499
[[Variables]]
    amplitude:   0.38116350 +/- 0.021523 (5.65%) (init= 0.5)
    decay:       0.28843181 +/- 0.026043 (9.03%) (init= 0.5)
    c:           0.05999996 +/- 0.002984 (4.97%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.610
    C(decay, c)                  = -0.325

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 19
    # data points      = 150
    # variables        = 3
    chi-square         = 0.072
    reduced chi-square = 0.000
    Akaike info crit   = -1141.152
    Bayesian info crit = -1132.120
[[Variables]]
    amplitude:   0.31922745 +/- 0.012870 (4.03%) (init= 0.5)
    decay:       0.54684409 +/- 0.034062 (6.23%) (init= 0.5)
    c:           0.04289024 +/- 0.002260 (5.27%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.658
    C(decay, c)                  = -0.472

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 150
    # variables        = 1
    chi-square         = 0.569
    reduced chi-square = 0.004
    Akaike info crit   = -834.177
    Bayesian info crit = -831.166
[[Variables]]
    c:   0.07928571 +/- 0.005045 (6.36%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 149
    # variables        = 1
    chi-square         = 0.532
    reduced chi-square = 0.004
    Akaike info crit   = -837.676
    Bayesian info crit = -834.672
[[Variables]]
    c:   0.06918037 +/- 0.004910 (7.10%) (init= 0.03)

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