H12 / Gabon An. gambiae / Chromosome 2 / #3

This page describes a signal of selection found in the Gabon An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 39,620,001 and 39,680,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

No genes overlap the focal region.

Gene AGAP003568 (COE22933 - carboxylesterase) is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 42
    # data points      = 148
    # variables        = 3
    chi-square         = 0.030
    reduced chi-square = 0.000
    Akaike info crit   = -1251.893
    Bayesian info crit = -1242.901
[[Variables]]
    amplitude:   0.06420264 +/- 0.011686 (18.20%) (init= 0.5)
    decay:       0.15000014 +/- 0.045040 (30.03%) (init= 0.5)
    c:           0.04215397 +/- 0.001250 (2.97%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.581
    C(decay, c)                  = -0.232

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 39
    # data points      = 147
    # variables        = 3
    chi-square         = 0.030
    reduced chi-square = 0.000
    Akaike info crit   = -1242.045
    Bayesian info crit = -1233.074
[[Variables]]
    amplitude:   0.04600719 +/- 0.005898 (12.82%) (init= 0.5)
    decay:       1.04402697 +/- 0.262260 (25.12%) (init= 0.5)
    c:           0.03582062 +/- 0.002094 (5.85%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.706
    C(amplitude, decay)          = -0.509

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 147
    # variables        = 1
    chi-square         = 0.036
    reduced chi-square = 0.000
    Akaike info crit   = -1221.215
    Bayesian info crit = -1218.224
[[Variables]]
    c:   0.04358752 +/- 0.001290 (2.96%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 146
    # variables        = 1
    chi-square         = 0.043
    reduced chi-square = 0.000
    Akaike info crit   = -1185.618
    Bayesian info crit = -1182.634
[[Variables]]
    c:   0.04333567 +/- 0.001422 (3.28%) (init= 0.03)

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