H12 / Gabon An. gambiae / Chromosome 2 / #5

This page describes a signal of selection found in the Gabon An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 28,440,001 and 28,580,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 26 genes overlap the focal region: AGAP028453, AGAP006214, AGAP006215 (GPRMTH1 - methuselah receptor 1), AGAP006216 (GPRMTH2 - methuselah receptor 2), AGAP006217, AGAP006218 (GPRMTH4 - methuselah receptor 4), AGAP006219 (receptor tyrosine kinase-like orphan receptor 1), AGAP0062201 (aldehyde oxidase), AGAP0062211 (aldehyde oxidase), AGAP006222 (glucosyl/glucuronosyl transferases), AGAP006223 (glucosyl/glucuronosyl transferases), AGAP0062241 (aldehyde oxidase), AGAP0062251 (aldehyde oxidase), AGAP0062261 (Aldehyde_oxidase), AGAP0062271 (alpha esterase), AGAP0062281 (COEAE2F - carboxylesterase), AGAP006229 (Vps20 - vacuolar protein sorting 20), AGAP006231 (serine/threonine-protein phosphatase dullard homolog), AGAP006232 (peroxin-14), AGAP006233, AGAP006234 (protein SHQ1), AGAP006235, AGAP006236, AGAP006237 (Negative elongation factor E), AGAP006238 (ubiquitin-conjugating enzyme E2 C), AGAP006239 (Protein TSSC1).

The following 16 genes are within 50 kbp of the focal region: AGAP006240 (splicing factor 3B subunit 2), AGAP006241 (Innexin inx2), AGAP006242, AGAP006243 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase), AGAP029069, AGAP006244 (CTL-like protein 1), AGAP006245 (zinc finger matrin-type protein 2), AGAP006246 (Sorcin), AGAP006247 (Survival of motor neuron-related-splicing factor 30), AGAP006248 (Med10 - Mediator of RNA polymerase II transcription subunit 10), AGAP006249 (solute carrier family 12 (potassium/chloride transporters), member 8), AGAP006250 (eukaryotic elongation factor, selenocysteine-tRNA-specific), AGAP006251 (syntaxin 6), AGAP006252 (Cysteine-rich venom protein), AGAP006253 (Cysteine-rich venom protein), AGAP006254 (polypeptide N-acetylglucosaminyltransferase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Burkina Faso An. gambiae / Chromosome 2 / #2 2L:28,500,001-28,640,000 954 (431 | 523)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 36
    # data points      = 151
    # variables        = 3
    chi-square         = 0.079
    reduced chi-square = 0.001
    Akaike info crit   = -1135.006
    Bayesian info crit = -1125.954
[[Variables]]
    amplitude:   0.08020083 +/- 0.018721 (23.34%) (init= 0.5)
    decay:       0.15000000 +/- 0.090357 (60.24%) (init= 0.5)
    c:           0.04792015 +/- 0.001981 (4.13%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          =  0.581
    C(decay, c)                  =  0.229

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 27
    # data points      = 143
    # variables        = 3
    chi-square         = 0.024
    reduced chi-square = 0.000
    Akaike info crit   = -1238.680
    Bayesian info crit = -1229.792
[[Variables]]
    amplitude:   0.07102244 +/- 0.011021 (15.52%) (init= 0.5)
    decay:       0.29636133 +/- 0.064504 (21.77%) (init= 0.5)
    c:           0.03308017 +/- 0.001222 (3.70%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.719
    C(decay, c)                  = -0.340

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 150
    # variables        = 1
    chi-square         = 0.088
    reduced chi-square = 0.001
    Akaike info crit   = -1114.756
    Bayesian info crit = -1111.745
[[Variables]]
    c:   0.04967137 +/- 0.001980 (3.99%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 142
    # variables        = 1
    chi-square         = 0.035
    reduced chi-square = 0.000
    Akaike info crit   = -1178.313
    Bayesian info crit = -1175.357
[[Variables]]
    c:   0.03610502 +/- 0.001319 (3.65%) (init= 0.03)

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