H12 / Gabon An. gambiae / Chromosome 2 / #6

This page describes a signal of selection found in the Gabon An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 44,380,001 and 44,580,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 7 genes overlap the focal region: AGAP003849, AGAP013134, AGAP003851 (26 proteasome complex subunit DSS1), AGAP003852 (snRNA-activating protein complex subunit 3), AGAP003853 (ubiquitin thioesterase ZRANB1), AGAP029103, AGAP003855.

The following 7 genes are within 50 kbp of the focal region: AGAP003844 (Class b basic helix-loop-helix protein), AGAP003845 (bromodomain-containing protein 8), AGAP003846 (secretory phospholipase A2), AGAP003847 (RNA exonuclease 1), AGAP003848 (acyl-CoA thioesterase 9.1), AGAP013342, AGAP013408.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 39
    # data points      = 148
    # variables        = 3
    chi-square         = 0.025
    reduced chi-square = 0.000
    Akaike info crit   = -1279.573
    Bayesian info crit = -1270.581
[[Variables]]
    amplitude:   0.03584757 +/- 0.004211 (11.75%) (init= 0.5)
    decay:       1.99999993 +/- 0.723105 (36.16%) (init= 0.5)
    c:           0.03451687 +/- 0.004065 (11.78%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.906
    C(amplitude, c)              = -0.474
    C(amplitude, decay)          =  0.164

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 39
    # data points      = 139
    # variables        = 3
    chi-square         = 0.055
    reduced chi-square = 0.000
    Akaike info crit   = -1081.967
    Bayesian info crit = -1073.164
[[Variables]]
    amplitude:   0.06004666 +/- 0.016489 (27.46%) (init= 0.5)
    decay:       0.31321126 +/- 0.121904 (38.92%) (init= 0.5)
    c:           0.05186095 +/- 0.001945 (3.75%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.713
    C(decay, c)                  = -0.356

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 147
    # variables        = 1
    chi-square         = 0.036
    reduced chi-square = 0.000
    Akaike info crit   = -1222.085
    Bayesian info crit = -1219.094
[[Variables]]
    c:   0.04576977 +/- 0.001287 (2.81%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 138
    # variables        = 1
    chi-square         = 0.063
    reduced chi-square = 0.000
    Akaike info crit   = -1059.324
    Bayesian info crit = -1056.396
[[Variables]]
    c:   0.05461355 +/- 0.001826 (3.34%) (init= 0.03)

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