H12 / Gabon An. gambiae / Chromosome 3 / #2

This page describes a signal of selection found in the Gabon An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 80,001 and 180,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 8 genes overlap the focal region: AGAP007735, AGAP007736, AGAP007737, AGAP007738, AGAP007739 (transducin (beta)-like 1), AGAP007740 (RpLP1 - 60S ribosomal protein LP1), AGAP007741 (ribonuclease H2 subunit A), AGAP007742 (E3 UFM1-protein ligase 1 homolog).

The following 13 genes are within 50 kbp of the focal region: AGAP007732 (solute carrier family 17, member 5), AGAP007733 (Sialin), AGAP007734, AGAP007743 (solute carrier family 16 (monocarboxylic acid transporters), member 10), AGAP007744, AGAP007746, AGAP007745, AGAP007747, AGAP013766, AGAP007748, AGAP007749, AGAP007750, AGAP007751.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 58
    # data points      = 7
    # variables        = 3
    chi-square         = 0.000
    reduced chi-square = 0.000
    Akaike info crit   = -60.949
    Bayesian info crit = -61.112
[[Variables]]
    amplitude:   0.21411571 +/- 0.095583 (44.64%) (init= 0.5)
    decay:       0.25358981 +/- 0.183585 (72.39%) (init= 0.5)
    c:           2.0761e-12 +/- 0.002020 (97315315354.63%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, c)              =  0.996
    C(decay, c)                  =  0.990
    C(amplitude, decay)          =  0.977

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 39
    # data points      = 149
    # variables        = 3
    chi-square         = 0.094
    reduced chi-square = 0.001
    Akaike info crit   = -1092.678
    Bayesian info crit = -1083.667
[[Variables]]
    amplitude:   0.12667533 +/- 0.008266 (6.53%) (init= 0.5)
    decay:       1.68756125 +/- 0.306421 (18.16%) (init= 0.5)
    c:           0.01807777 +/- 0.006122 (33.87%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.868
    C(amplitude, c)              = -0.228
    C(amplitude, decay)          = -0.150

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 6
    # variables        = 1
    chi-square         = 0.009
    reduced chi-square = 0.002
    Akaike info crit   = -36.967
    Bayesian info crit = -37.175
[[Variables]]
    c:   0.12906569 +/- 0.017388 (13.47%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 148
    # variables        = 1
    chi-square         = 0.229
    reduced chi-square = 0.002
    Akaike info crit   = -956.021
    Bayesian info crit = -953.023
[[Variables]]
    c:   0.05156228 +/- 0.003241 (6.29%) (init= 0.03)

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