H12 / Guinea An. gambiae / Chromosome 2 / #6

This page describes a signal of selection found in the Guinea An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 56,440,001 and 56,520,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP013508, AGAP004453 (GPRDOP3 - GPCR Dopamine Family 3).

Gene AGAP004452 is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 601
    # data points      = 143
    # variables        = 3
    chi-square         = 0.068
    reduced chi-square = 0.000
    Akaike info crit   = -1087.617
    Bayesian info crit = -1078.728
[[Variables]]
    amplitude:   0.06071392 +/- 0.007143 (11.77%) (init= 0.5)
    decay:       1.99998163 +/- 0.711613 (35.58%) (init= 0.5)
    c:           0.05999999 +/- 0.000426 (0.71%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.904
    C(amplitude, c)              = -0.478
    C(amplitude, decay)          =  0.166

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 48
    # data points      = 213
    # variables        = 3
    chi-square         = 0.308
    reduced chi-square = 0.001
    Akaike info crit   = -1387.005
    Bayesian info crit = -1376.921
[[Variables]]
    amplitude:   0.11612259 +/- 0.011008 (9.48%) (init= 0.5)
    decay:       1.99999997 +/- 1.479006 (73.95%) (init= 0.5)
    c:           0.04683244 +/- 0.008300 (17.72%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  =  0.896
    C(amplitude, decay)          =  0.178
    C(amplitude, c)              = -0.148

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 142
    # variables        = 1
    chi-square         = 0.084
    reduced chi-square = 0.001
    Akaike info crit   = -1052.993
    Bayesian info crit = -1050.037
[[Variables]]
    c:   0.08082103 +/- 0.002051 (2.54%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 212
    # variables        = 1
    chi-square         = 0.460
    reduced chi-square = 0.002
    Akaike info crit   = -1298.146
    Bayesian info crit = -1294.789
[[Variables]]
    c:   0.07400610 +/- 0.003207 (4.33%) (init= 0.03)

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