H12 / Guinea Bissau / Chromosome 2 / #4

This page describes a signal of selection found in the Guinea Bissau population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 7,880,001 and 7,920,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP001674 (sidestep) overlaps the focal region.

The following 2 genes are within 50 kbp of the focal region: AGAP013191, AGAP001675.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 31
    # data points      = 151
    # variables        = 3
    chi-square         = 0.164
    reduced chi-square = 0.001
    Akaike info crit   = -1024.537
    Bayesian info crit = -1015.485
[[Variables]]
    amplitude:   0.11556255 +/- 0.011473 (9.93%) (init= 0.5)
    decay:       1.28424294 +/- 0.290197 (22.60%) (init= 0.5)
    c:           0.04639043 +/- 0.005644 (12.17%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.777
    C(amplitude, decay)          = -0.356
    C(amplitude, c)              = -0.103

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 108
    # data points      = 133
    # variables        = 3
    chi-square         = 0.368
    reduced chi-square = 0.003
    Akaike info crit   = -777.391
    Bayesian info crit = -768.720
[[Variables]]
    amplitude:   0.70062682 +/- 0.073522 (10.49%) (init= 0.5)
    decay:       0.15000002 +/- 0.008914 (5.94%) (init= 0.5)
    c:           0.05999999 +/- 0.023579 (39.30%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.780
    C(decay, c)                  =  0.245

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 150
    # variables        = 1
    chi-square         = 0.256
    reduced chi-square = 0.002
    Akaike info crit   = -953.794
    Bayesian info crit = -950.784
[[Variables]]
    c:   0.06985034 +/- 0.003386 (4.85%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 132
    # variables        = 1
    chi-square         = 0.640
    reduced chi-square = 0.005
    Akaike info crit   = -701.446
    Bayesian info crit = -698.563
[[Variables]]
    c:   0.09384308 +/- 0.006083 (6.48%) (init= 0.03)

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