H12 / Angola An. coluzzii / Chromosome 2 / #3

This page describes a signal of selection found in the Angola An. coluzzii population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 25,380,001 and 25,460,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 3 genes overlap the focal region: AGAP0060282 (Rdl - GABA-gated chloride channel subunit), AGAP006029, AGAP006030 (mfrn - mitoferrin).

The following 4 genes are within 50 kbp of the focal region: AGAP006031 (nuclear pore complex protein Nup54), AGAP006032, AGAP006033, AGAP006034.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Burkina Faso An. coluzzii / Chromosome 2 / #2 2L:25,400,001-25,520,000 919 (426 | 492)
H12 / Burkina Faso An. gambiae / Chromosome 2 / #5 2L:25,380,001-25,420,000 409 (195 | 214)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 27
    # data points      = 201
    # variables        = 3
    chi-square         = 0.021
    reduced chi-square = 0.000
    Akaike info crit   = -1839.589
    Bayesian info crit = -1829.679
[[Variables]]
    amplitude:   0.09838622 +/- 0.005458 (5.55%) (init= 0.5)
    decay:       0.47672673 +/- 0.041888 (8.79%) (init= 0.5)
    c:           0.02451441 +/- 0.000825 (3.37%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.621
    C(decay, c)                  = -0.367

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 31
    # data points      = 200
    # variables        = 3
    chi-square         = 0.036
    reduced chi-square = 0.000
    Akaike info crit   = -1718.842
    Bayesian info crit = -1708.947
[[Variables]]
    amplitude:   0.05934914 +/- 0.003862 (6.51%) (init= 0.5)
    decay:       2.12598195 +/- 0.365931 (17.21%) (init= 0.5)
    c:           0.02048246 +/- 0.002586 (12.63%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.851
    C(amplitude, decay)          = -0.218
    C(amplitude, c)              = -0.180

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 200
    # variables        = 1
    chi-square         = 0.067
    reduced chi-square = 0.000
    Akaike info crit   = -1597.587
    Bayesian info crit = -1594.288
[[Variables]]
    c:   0.03013194 +/- 0.001299 (4.31%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 199
    # variables        = 1
    chi-square         = 0.074
    reduced chi-square = 0.000
    Akaike info crit   = -1568.797
    Bayesian info crit = -1565.503
[[Variables]]
    c:   0.03532733 +/- 0.001372 (3.89%) (init= 0.03)

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