H12 / Burkina Faso An. gambiae / Chromosome X / #1

This page describes a signal of selection found in the Burkina Faso An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 15,120,001 and 15,260,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 3 genes overlap the focal region: AGAP012997, AGAP0008181 (CYP9K1 - cytochrome P450), AGAP000819 (nuclear receptor subfamily 2 group E member (Tailless)).

The following 3 genes are within 50 kbp of the focal region: AGAP013424, AGAP0008204 (CPR125 - cuticular protein RR-2 family 125), AGAP000821.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Burkina Faso An. coluzzii / Chromosome X / #1 X:15,100,001-15,380,000 954 (534 | 420)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 19
    # data points      = 146
    # variables        = 3
    chi-square         = 0.034
    reduced chi-square = 0.000
    Akaike info crit   = -1216.298
    Bayesian info crit = -1207.348
[[Variables]]
    amplitude:   0.44556414 +/- 0.007692 (1.73%) (init= 0.5)
    decay:       0.65192407 +/- 0.018025 (2.76%) (init= 0.5)
    c:           0.01449774 +/- 0.001661 (11.46%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.525
    C(amplitude, decay)          = -0.520

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 19
    # data points      = 146
    # variables        = 3
    chi-square         = 0.082
    reduced chi-square = 0.001
    Akaike info crit   = -1087.426
    Bayesian info crit = -1078.475
[[Variables]]
    amplitude:   0.49155334 +/- 0.017368 (3.53%) (init= 0.5)
    decay:       0.45628987 +/- 0.022483 (4.93%) (init= 0.5)
    c:           0.05582530 +/- 0.002376 (4.26%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.710
    C(decay, c)                  = -0.427

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 145
    # variables        = 1
    chi-square         = 0.984
    reduced chi-square = 0.007
    Akaike info crit   = -721.895
    Bayesian info crit = -718.918
[[Variables]]
    c:   0.05387687 +/- 0.006866 (12.74%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 145
    # variables        = 1
    chi-square         = 0.839
    reduced chi-square = 0.006
    Akaike info crit   = -744.996
    Bayesian info crit = -742.019
[[Variables]]
    c:   0.08695567 +/- 0.006340 (7.29%) (init= 0.03)

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