H12 / Cameroon An. gambiae / Chromosome 2 / #3

This page describes a signal of selection found in the Cameroon An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 40,600,001 and 40,980,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 27 genes overlap the focal region: AGAP003623 (long-chain acyl-CoA synthetase), AGAP003624, AGAP029110, AGAP003626, AGAP013221, AGAP012946, AGAP003627, AGAP003629, AGAP003630, AGAP003631 (GPRGRP2 - putative gastrin/bombesin receptor 2), AGAP003632 (U3 small nucleolar RNA-associated protein 14), AGAP003633, AGAP003635, AGAP0036361 (inositol oxygenase), AGAP003638, AGAP003639 (Prolylcarboxypeptidase), AGAP0036401 (SP8905), AGAP0036411 (SP8907), AGAP0036421 (SP8898), AGAP003643 (ubiquitin carboxyl-terminal hydrolase 34), AGAP003644 (mRpS11 - 28S ribosomal protein S11, mitochondrial), AGAP003645 (kelch-like protein 19), AGAP013307, AGAP003646, AGAP003647, AGAP003648 (DNA-directed RNA polymerase II subunit RPB2), AGAP003649.

The following 10 genes are within 50 kbp of the focal region: AGAP029083, AGAP003615 (toll-interacting protein), AGAP003616, AGAP003618 (serine/threonine-protein kinase LATS1/2), AGAP003619 (transcription elongation factor SPT6), AGAP003620, AGAP003621 (coiled-coil domain-containing protein 25), AGAP003622 (Queuine tRNA-ribosyltransferase catalytic subunit 1), AGAP003650 (translation initiation factor eIF-2B subunit alpha), AGAP003651 (Tyrosine-protein kinase Fes/Fps).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Burkina Faso An. coluzzii / Chromosome 2 / #4 2R:40,880,001-40,980,000 400 (185 | 214)
H12 / Burkina Faso An. gambiae / Chromosome 2 / #6 2R:40,820,001-41,000,000 359 (249 | 109)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 43
    # data points      = 150
    # variables        = 3
    chi-square         = 0.027
    reduced chi-square = 0.000
    Akaike info crit   = -1285.215
    Bayesian info crit = -1276.183
[[Variables]]
    amplitude:   0.09174235 +/- 0.004350 (4.74%) (init= 0.5)
    decay:       1.99999998 +/- 0.291781 (14.59%) (init= 0.5)
    c:           0.01941933 +/- 0.004175 (21.50%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.906
    C(amplitude, c)              = -0.466
    C(amplitude, decay)          =  0.155

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 45
    # data points      = 147
    # variables        = 3
    chi-square         = 0.046
    reduced chi-square = 0.000
    Akaike info crit   = -1181.198
    Bayesian info crit = -1172.227
[[Variables]]
    amplitude:   0.05634944 +/- 0.005782 (10.26%) (init= 0.5)
    decay:       1.99999849 +/- 0.641559 (32.08%) (init= 0.5)
    c:           0.05197010 +/- 0.005541 (10.66%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.907
    C(amplitude, c)              = -0.422
    C(amplitude, decay)          =  0.107

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 149
    # variables        = 1
    chi-square         = 0.098
    reduced chi-square = 0.001
    Akaike info crit   = -1089.847
    Bayesian info crit = -1086.843
[[Variables]]
    c:   0.04796618 +/- 0.002106 (4.39%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 146
    # variables        = 1
    chi-square         = 0.074
    reduced chi-square = 0.001
    Akaike info crit   = -1106.733
    Bayesian info crit = -1103.750
[[Variables]]
    c:   0.06940894 +/- 0.001863 (2.68%) (init= 0.03)

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