This page describes a signal of selection found in the
Guinea An. gambiae population using the
H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm
2L between positions 1,760,001 and
2,700,000.
The evidence supporting this signal is
strong ( >= 100 on both flanks).
Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.
The following 25 genes overlap the focal region: AGAP028435, AGAP004695 (ESCRT-I complex subunit MVB12), AGAP004696 (exd - Homeobox protein extradenticle), AGAP004698 (pre-mRNA-splicing factor 38B), AGAP004699 (RAF proto-oncogene serine/threonine-protein kinase), AGAP004700, AGAP004701, AGAP028436, AGAP004702, AGAP004703 (DNA-directed RNA polymerase III subunit RPC1), AGAP004704 (COMPASS component SPP1), AGAP028437, AGAP004706, AGAP0047072 (para - voltage-gated sodium channel), AGAP004708 (arginyl-tRNA synthetase), AGAP004709 (mRpL18 - 39S ribosomal protein L18, mitochondrial), AGAP0047101 (ubiquinol-cytochrome c reductase subunit 9), AGAP004711 (ATP-dependent RNA helicase DDX41), AGAP004712, AGAP004713, AGAP004714, AGAP0047151 (Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial), AGAP0047163 (Gr57 - gustatory receptor 57), AGAP004717, AGAP004718.
The following 3 genes are within 50 kbp of the focal region: AGAP004719 (CLIPC9 - CLIP-domain serine protease), AGAP004720, AGAP004721 (N-acetylglucosamine-6-sulfatase).
Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.
The following selection signals have a focus which overlaps with the focus of this signal.
Signal | Focus | Score (Left | Right) |
---|---|---|
H12 / Burkina Faso An. coluzzii / Chromosome 2 / #1 | 2L:2,520,001-2,900,000 | 1399 (800 | 599) |
H12 / Burkina Faso An. gambiae / Chromosome 2 / #1 | 2L:2,420,001-2,720,000 | 1365 (680 | 685) |
H12 / Uganda An. gambiae / Chromosome 2 / #2 | 2L:2,520,001-3,120,000 | 982 (573 | 409) |
H12 / Cameroon An. gambiae / Chromosome 2 / #2 | 2L:2,420,001-2,920,000 | 566 (461 | 104) |
H12 / Gabon An. gambiae / Chromosome 2 / #2 | 2L:2,600,001-2,640,000 | 274 (223 | 51) |
The information below provides some diagnostics from the Peak modelling algorithm.
Selection signal in context. @@TODO
Peak targetting. @@TODO
Peak fitting diagnostics. @@TODO
Left flank, peak model:
[[Model]]
Model(exponential)
[[Fit Statistics]]
# function evals = 144
# data points = 310
# variables = 3
chi-square = 3.384
reduced chi-square = 0.011
Akaike info crit = -1394.419
Bayesian info crit = -1383.210
[[Variables]]
amplitude: 1.47883312 +/- 0.058806 (3.98%) (init= 0.5)
decay: 0.94720432 +/- 0.054588 (5.76%) (init= 0.5)
c: 0.05999999 +/- 0.022960 (38.27%) (init= 0.03)
cap: 1 (fixed)
[[Correlations]] (unreported correlations are < 0.100)
C(amplitude, decay) = -0.788
C(decay, c) = 0.758
C(amplitude, c) = -0.308
Right flank, peak model:
[[Model]]
Model(exponential)
[[Fit Statistics]]
# function evals = 59
# data points = 179
# variables = 3
chi-square = 0.477
reduced chi-square = 0.003
Akaike info crit = -1054.956
Bayesian info crit = -1045.394
[[Variables]]
amplitude: 0.89482007 +/- 0.012836 (1.43%) (init= 0.5)
decay: 1.24021888 +/- 0.048271 (3.89%) (init= 0.5)
c: 0.05999999 +/- 0.007524 (12.54%) (init= 0.03)
cap: 1 (fixed)
[[Correlations]] (unreported correlations are < 0.100)
C(decay, c) = -0.748
C(amplitude, c) = -0.303
C(amplitude, decay) = -0.146
Left flank, null model:
[[Model]]
Model(constant)
[[Fit Statistics]]
# function evals = 6
# data points = 305
# variables = 1
chi-square = 28.489
reduced chi-square = 0.094
Akaike info crit = -721.092
Bayesian info crit = -717.372
[[Variables]]
c: 0.40071818 +/- 0.017528 (4.37%) (init= 0.03)
Right flank, null model:
[[Model]]
Model(constant)
[[Fit Statistics]]
# function evals = 6
# data points = 176
# variables = 1
chi-square = 11.947
reduced chi-square = 0.068
Akaike info crit = -471.448
Bayesian info crit = -468.277
[[Variables]]
c: 0.27741581 +/- 0.019694 (7.10%) (init= 0.03)