H12 / Guinea An. gambiae / Chromosome 3 / #2

This page describes a signal of selection found in the Guinea An. gambiae population using the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 4,580,001 and 4,740,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP028427 overlaps the focal region.

The following 7 genes are within 50 kbp of the focal region: AGAP008028 (voltage-dependent calcium channel beta, invertebrate), AGAP008033, AGAP013760, AGAP008034 (solute carrier family 39 (zinc transporter), member 7), AGAP008035, AGAP008036, AGAP008037 (KDEL (Lys-Asp-Glu-Leu) containing 1, isoform CRA_a).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Focus Score (Left | Right)
H12 / Burkina Faso An. gambiae / Chromosome 3 / #3 3R:4,580,001-4,760,000 167 (145 | 21)

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Left flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 27
    # data points      = 151
    # variables        = 3
    chi-square         = 0.005
    reduced chi-square = 0.000
    Akaike info crit   = -1557.306
    Bayesian info crit = -1548.255
[[Variables]]
    amplitude:   0.03225017 +/- 0.002244 (6.96%) (init= 0.5)
    decay:       0.95308210 +/- 0.127737 (13.40%) (init= 0.5)
    c:           0.02107194 +/- 0.000748 (3.55%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.662
    C(amplitude, decay)          = -0.491

Right flank, peak model:

[[Model]]
    Model(exponential)
[[Fit Statistics]]
    # function evals   = 75
    # data points      = 150
    # variables        = 3
    chi-square         = 0.008
    reduced chi-square = 0.000
    Akaike info crit   = -1476.633
    Bayesian info crit = -1467.601
[[Variables]]
    amplitude:   0.02719245 +/- 0.002824 (10.39%) (init= 0.5)
    decay:       1.12208621 +/- 0.236980 (21.12%) (init= 0.5)
    c:           0.02441456 +/- 0.001085 (4.44%) (init= 0.03)
    cap:         1 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, c)                  = -0.729
    C(amplitude, decay)          = -0.484

Left flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 150
    # variables        = 1
    chi-square         = 0.013
    reduced chi-square = 0.000
    Akaike info crit   = -1404.450
    Bayesian info crit = -1401.439
[[Variables]]
    c:   0.02605272 +/- 0.000754 (2.89%) (init= 0.03)

Right flank, null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 6
    # data points      = 149
    # variables        = 1
    chi-square         = 0.013
    reduced chi-square = 0.000
    Akaike info crit   = -1393.695
    Bayesian info crit = -1390.691
[[Variables]]
    c:   0.02915377 +/- 0.000760 (2.61%) (init= 0.03)

Comments