Gste locus¶
This page provides information about the Glutathione S-transferase epsilon gene cluster, a locus for which there is prior evidence of recent positive selection and/or an association with insecticide resistance in Anopheles mosquitoes.
The locus occurs on chromosome arm 3R from position 28,591,663 to 28,602,280.
The locus contains the following 8 genes: AGAP009190 (GSTE8 - glutathione S-transferase epsilon class 8), AGAP009191 (GSTE6 - glutathione S-transferase epsilon class 6), AGAP009192 (GSTE5 - glutathione S-transferase epsilon class 5), AGAP009193 (GSTE4 - glutathione S-transferase epsilon class 4), AGAP009194 (GSTE2 - glutathione S-transferase epsilon class 2), AGAP009195 (GSTE1 - glutathione S-transferase epsilon class 1), AGAP009196 (GSTE7 - glutathione S-transferase epsilon class 7), AGAP009197 (GSTE3 - glutathione S-transferase epsilon class 3).
References¶
- Mitchell et al. (2014) Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae
Selection signals¶
The table below lists signals of recent selection found in this study that are overlapping or within 50 kbp of this locus.
| Signal | Statistic | Population | Focus | Peak model  |
Max. percentile | Known locus |
|---|---|---|---|---|---|---|
| H12/CMS/3/1 | H12 | Cameroon An. gambiae | 3R:28,580,000-28,620,000 | 1,410 | 100.0% | Gste |
| XPEHH/CMS.GWA/3/1 | XPEHH | Cameroon An. gambiae | 3R:28,600,000-28,700,000 | 1,275 | 100.0% | Gste |
| XPEHH/BFS.GWA/3/1 | XPEHH | Burkina Faso An. gambiae | 3R:28,500,000-28,620,000 | 1,181 | 100.0% | Gste |
| IHS/CMS/3/1 | IHS | Cameroon An. gambiae | 3R:28,320,000-28,700,000 | 1,106 | 100.0% | Gste |
| IHS/BFM/3/1 | IHS | Burkina Faso An. coluzzii | 3R:28,260,000-28,620,000 | 1,058 | 100.0% | Gste |
| H12/BFS/3/1 | H12 | Burkina Faso An. gambiae | 3R:28,520,000-28,580,000 | 995 | 98.4% | Gste |
| H12/UGS/3/1 | H12 | Uganda An. gambiae | 3R:28,560,000-28,600,000 | 876 | 97.3% | Gste |
| XPEHH/BFM.GWA/3/1 | XPEHH | Burkina Faso An. coluzzii | 3R:28,600,000-28,660,000 | 767 | 100.0% | Gste |
| H12/BFM/3/1 | H12 | Burkina Faso An. coluzzii | 3R:28,560,000-28,620,000 | 747 | 98.0% | Gste |
| XPEHH/UGS.GWA/3/1 | XPEHH | Uganda An. gambiae | 3R:28,540,000-28,600,000 | 662 | 100.0% | Gste |
| XPEHH/BFM.AOM/3/1 | XPEHH | Burkina Faso An. coluzzii | 3R:28,600,000-28,640,000 | 569 | 100.0% | Gste |
| IHS/UGS/3/1 | IHS | Uganda An. gambiae | 3R:28,440,000-28,640,000 | 493 | 99.7% | Gste |
| XPEHH/GAS.GWA/3/1 | XPEHH | Gabon An. gambiae | 3R:28,540,000-28,620,000 | 129 | 100.0% | Gste |