Rdl locus

This page provides information about the GABA-gated chloride channel subunit gene, a locus for which there is prior evidence of recent positive selection and/or an association with insecticide resistance in Anopheles mosquitoes.

The locus occurs on chromosome arm 2L from position 25,363,652 to 25,434,556.

The locus contains gene AGAP006028 (Rdl - GABA-gated chloride channel subunit).

References

  • Du et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis

Selection signals

The table below lists signals of recent selection found in this study that are overlapping or within 50 kbp of this locus.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/BFM/2/2 H12 Burkina Faso An. coluzzii 2L:25,434,895-25,494,895 1,172 98.4% Rdl
XPEHH/BFM.GWA/2/2 XPEHH Burkina Faso An. coluzzii 2L:25,474,895-25,514,895 625 99.4% Rdl
H12/GAS/2/1 H12 Gabon An. gambiae 2L:25,454,895-25,514,895 529 100.0% Rdl
XPEHH/BFM.BFS/2/1 XPEHH Burkina Faso An. coluzzii 2L:25,454,895-25,554,895 468 99.3% Rdl
XPEHH/GAS.GWA/2/1 XPEHH Gabon An. gambiae 2L:25,474,895-25,634,895 423 100.0% Rdl
H12/AOM/2/3 H12 Angola An. coluzzii 2L:25,214,895-25,334,895 398 95.7% Rdl
XPEHH/BFS.UGS/2/4 XPEHH Burkina Faso An. gambiae 2L:25,434,895-25,474,895 388 98.3% Rdl
H12/BFS/2/5 H12 Burkina Faso An. gambiae 2L:25,454,895-25,534,895 375 96.1% Rdl
IHS/BFM/2/3 IHS Burkina Faso An. coluzzii 2L:24,754,895-25,434,895 304 99.9% Rdl
XPEHH/CMS.UGS/2/2 XPEHH Cameroon An. gambiae 2L:25,414,895-25,454,895 291 90.3% Rdl
IHS/BFS/2/5 IHS Burkina Faso An. gambiae 2L:25,434,895-25,614,895 256 99.8% Rdl
XPEHH/BFS.GWA/2/6 XPEHH Burkina Faso An. gambiae 2L:25,434,895-25,474,895 138 95.3% Rdl
XPEHH/AOM.GWA/2/6 XPEHH Angola An. coluzzii 2L:25,254,895-25,414,895 92 83.9% Rdl

Comments