Vgsc locus

This page provides information about the Voltage-gated sodium channel gene, a locus for which there is prior evidence of recent positive selection and/or an association with insecticide resistance in Anopheles mosquitoes.

The locus occurs on chromosome arm 2L from position 2,358,158 to 2,431,617.

The locus contains gene AGAP004707 (para - voltage-gated sodium channel).

References

  • Martinez-Torres et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s.
  • Ranson et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids
  • Davies et al. (2007) A comparative study of voltage-gated sodium channels in the Insecta: implications for pyrethroid resistance in Anopheline and other Neopteran species
  • Lynd et al. (2010) Field, genetic, and modeling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s.
  • Jones et al. (2015) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium channel of Anopheles gambiae

Selection signals

The table below lists signals of recent selection found in this study that are overlapping or within 50 kbp of this locus.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/BFM/2/1 H12 Burkina Faso An. coluzzii 2L:2,474,895-2,894,895 1,800 99.9% Vgsc
H12/BFS/2/1 H12 Burkina Faso An. gambiae 2L:1,454,895-2,694,895 1,776 100.0% Vgsc
H12/GNS/2/1 H12 Guinea An. gambiae 2L:1,294,895-2,474,895 1,685 100.0% Vgsc
H12/UGS/2/2 H12 Uganda An. gambiae 2L:1,814,895-3,094,895 1,377 100.0% Vgsc
XPEHH/BFS.GWA/2/1 XPEHH Burkina Faso An. gambiae 2L:2,234,895-3,274,895 938 99.6% Vgsc
XPEHH/BFM.GWA/2/1 XPEHH Burkina Faso An. coluzzii 2L:2,334,895-2,974,895 917 99.8% Vgsc

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