H12/AOM/2/3

This page describes a signal of selection found in the Angola An. coluzzii populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 25,214,895 and 25,334,895. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

This signal occurs within 50 kbp of the Rdl locus, a genome region with prior evidence of an association with insecticide resistance and/or recent positive selection in Anopheles mosquitoes.

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP0060272 (glutamate receptor, ionotropic , AMPA) overlaps the focal region.

The following 3 genes are within 50 kbp of the focal region: AGAP006025 (Ras-like protein family member), AGAP0060262, AGAP0060282 (Rdl - GABA-gated chloride channel subunit).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/BFM/2/3 IHS Burkina Faso An. coluzzii 2L:24,754,895-25,434,895 304 99.9% Rdl
XPEHH/AOM.GWA/2/6 XPEHH Angola An. coluzzii 2L:25,254,895-25,414,895 92 83.9% Rdl

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 48
    # data points      = 400
    # variables        = 4
    chi-square         = 0.056
    reduced chi-square = 0.000
    Akaike info crit   = -3539.947
    Bayesian info crit = -3523.981
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.07523390 +/- 0.003447 (4.58%) (init= 0.5)
    decay:       0.76594228 +/- 0.064472 (8.42%) (init= 0.5)
    skew:       -0.99999999 +/- 0.036743 (3.67%) (init= 0)
    baseline:    0.02414295 +/- 0.000807 (3.34%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.535
    C(decay, baseline)           = -0.491
    C(decay, skew)               =  0.413

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 9
    # data points      = 399
    # variables        = 1
    chi-square         = 0.151
    reduced chi-square = 0.000
    Akaike info crit   = -3140.971
    Bayesian info crit = -3136.982
[[Variables]]
    c:   0.03288150 +/- 0.000976 (2.97%) (init= 0.03)

Comments