H12/AOM/3/1

This page describes a signal of selection found in the Angola An. coluzzii populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 5,639,316 and 5,819,316. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 5 genes overlap the focal region: AGAP010530 (CLIPE4 - CLIP-domain serine protease), AGAP010531 (fibrinogen-related protein 7), AGAP010534, AGAP010535 (3-demethylubiquinone-9 3-methyltransferase 2), AGAP010536 (nucleolar complex protein 2).

The following 6 genes are within 50 kbp of the focal region: AGAP010519 (kinesin-like protein unc-104), AGAP010520 (krueppel-like factor, other), AGAP010537 (hexaprenyldihydroxybenzoate methyltransferase), AGAP010538 (M-phase phosphoprotein), AGAP010539 (coiled-coil and C2 domain-containing protein 1-like), AGAP010540.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 65
    # data points      = 485
    # variables        = 4
    chi-square         = 0.073
    reduced chi-square = 0.000
    Akaike info crit   = -4258.198
    Bayesian info crit = -4241.461
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.03522293 +/- 0.002730 (7.75%) (init= 0.5)
    decay:       1.35056217 +/- 0.188681 (13.97%) (init= 0.5)
    skew:       -0.99999999 +/- 0.011694 (1.17%) (init= 0)
    baseline:    0.02942177 +/- 0.000846 (2.88%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.580
    C(amplitude, decay)          = -0.463
    C(decay, skew)               = -0.287
    C(amplitude, baseline)       = -0.112

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 9
    # data points      = 484
    # variables        = 1
    chi-square         = 0.104
    reduced chi-square = 0.000
    Akaike info crit   = -4085.105
    Bayesian info crit = -4080.923
[[Variables]]
    c:   0.03526716 +/- 0.000667 (1.89%) (init= 0.03)

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