H12/AOM/X/3

This page describes a signal of selection found in the Angola An. coluzzii populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 19,300,000 and 19,520,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 5 genes overlap the focal region: AGAP001011, AGAP0010123 (Or36 - odorant receptor 36), AGAP001013, AGAP001014, AGAP001015 (notch gene homolog 1).

Gene AGAP001010 (chondroitin sulfate synthase) is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 406
    # variables        = 4
    chi-square         = 0.143
    reduced chi-square = 0.000
    Akaike info crit   = -3221.300
    Bayesian info crit = -3205.275
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.04797921 +/- 0.003015 (6.28%) (init= 0.5)
    sigma:       1.81157458 +/- 0.156931 (8.66%) (init= 0.5)
    skew:        0.45020990 +/- 0.057244 (12.72%) (init= 0)
    baseline:    0.01808896 +/- 0.002513 (13.90%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, baseline)           = -0.816
    C(amplitude, baseline)       = -0.576
    C(sigma, skew)               =  0.211
    C(amplitude, sigma)          =  0.178

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 9
    # data points      = 405
    # variables        = 1
    chi-square         = 0.223
    reduced chi-square = 0.001
    Akaike info crit   = -3037.510
    Bayesian info crit = -3033.507
[[Variables]]
    c:   0.03541135 +/- 0.001167 (3.30%) (init= 0.03)

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