H12/GWA/2/3

This page describes a signal of selection found in the Guinea Bissau populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 11,234,895 and 11,334,895. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 3 genes overlap the focal region: AGAP005165, AGAP0051691, AGAP0051701.

The following 8 genes are within 50 kbp of the focal region: AGAP0051661, AGAP0051671 (short chain dehydrogenase/3-oxoacyl-(acyl-carrier protein) reductase), AGAP005168, AGAP005171 (Tctex1 domain-containing protein 4), AGAP005172, AGAP005173 (Px serine/threonine kinase), AGAP005174 (nucleoporin SEH1), AGAP005175 (acetyl-CoA carboxylase / biotin carboxylase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/GWA.BFS/2/1 XPEHH Guinea Bissau 2L:11,294,895-11,354,895 309 98.0% nan
XPEHH/GWA.BFM/2/1 XPEHH Guinea Bissau 2L:11,274,895-11,354,895 304 99.8% nan
XPEHH/BFM.BFS/2/4 XPEHH Burkina Faso An. coluzzii 2L:11,114,895-11,534,895 170 88.1% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 389
    # variables        = 4
    chi-square         = 0.267
    reduced chi-square = 0.001
    Akaike info crit   = -2826.231
    Bayesian info crit = -2810.377
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.17859913 +/- 0.013447 (7.53%) (init= 0.5)
    decay:       0.29114147 +/- 0.033252 (11.42%) (init= 0.5)
    skew:       -0.47836207 +/- 0.114459 (23.93%) (init= 0)
    baseline:    0.05445297 +/- 0.001453 (2.67%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.660
    C(decay, baseline)           = -0.286
    C(decay, skew)               =  0.223

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 388
    # variables        = 1
    chi-square         = 0.453
    reduced chi-square = 0.001
    Akaike info crit   = -2618.109
    Bayesian info crit = -2614.148
[[Variables]]
    c:   0.06099757 +/- 0.001736 (2.85%) (init= 0.03)

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