H12/UGS/2/4

This page describes a signal of selection found in the Uganda An. gambiae populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 51,020,000 and 51,120,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP004167, AGAP004169.

The following 5 genes are within 50 kbp of the focal region: AGAP004162 (myosin, light polypeptide 9, regulatory), AGAP0041631 (GSTD7 - glutathione S-transferase delta class 7), AGAP0041641 (GSTD1-4 - glutathione S-transferase delta class 1), AGAP0041651 (GSTD2 - glutathione S-transferase delta class 2), AGAP004166.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/UGS.GWA/2/3 XPEHH Uganda An. gambiae 2R:50,960,000-51,100,000 225 90.2% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 58
    # data points      = 390
    # variables        = 4
    chi-square         = 0.127
    reduced chi-square = 0.000
    Akaike info crit   = -3123.708
    Bayesian info crit = -3107.843
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.03200985 +/- 0.002601 (8.13%) (init= 0.5)
    sigma:       2.07031739 +/- 0.231140 (11.16%) (init= 0.5)
    skew:        0.11051085 +/- 0.099992 (90.48%) (init= 0)
    baseline:    0.05402677 +/- 0.001656 (3.07%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, baseline)           = -0.654
    C(amplitude, baseline)       = -0.455

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 389
    # variables        = 1
    chi-square         = 0.170
    reduced chi-square = 0.000
    Akaike info crit   = -3006.533
    Bayesian info crit = -3002.570
[[Variables]]
    c:   0.06433156 +/- 0.001062 (1.65%) (init= 0.03)

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