IHS/BFS/2/9

This page describes a signal of selection found in the Burkina Faso An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 39,020,000 and 39,140,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 14 genes overlap the focal region: AGAP003512, AGAP003513, AGAP003514, AGAP0035151 (NIT8537), AGAP013231 (Nitrilase homolog 2), AGAP0035161 (NIT8492), AGAP003517 (phenylalanyl-tRNA synthetase beta chain), AGAP003519 (ankyrin repeat domain-containing protein 17), AGAP003521 (alpha-2-macroglobulin receptor-associated protein), AGAP012974, AGAP0035221 (CYP329A1 - cytochrome P450), AGAP0035231 (hypoxia-inducible factor prolyl hydroxylase), AGAP003524 (transcription initiation factor TFIID subunit 5), AGAP003525 (CCR4-NOT transcription complex, subunit 2).

The following 3 genes are within 50 kbp of the focal region: AGAP003509 (Complexin, isoform V), AGAP003526 (asterless), AGAP003527 (O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 57
    # data points      = 572
    # variables        = 4
    chi-square         = 141.482
    reduced chi-square = 0.249
    Akaike info crit   = -791.064
    Bayesian info crit = -773.668
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.97598408 +/- 0.096930 (9.93%) (init= 3)
    sigma:       0.53561296 +/- 0.063152 (11.79%) (init= 0.5)
    skew:        0.43784971 +/- 0.133871 (30.57%) (init= 0)
    baseline:    1.95957883 +/- 0.023378 (1.19%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.499
    C(sigma, baseline)           = -0.266
    C(amplitude, baseline)       = -0.182

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 571
    # variables        = 1
    chi-square         = 170.938
    reduced chi-square = 0.300
    Akaike info crit   = -686.675
    Bayesian info crit = -682.328
[[Variables]]
    c:   2.05485445 +/- 0.022917 (1.12%) (init= 1)

Comments