IHS/BFS/3/1

This page describes a signal of selection found in the Burkina Faso An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 27,940,000 and 28,260,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 20 genes overlap the focal region: AGAP009163, AGAP009164, AGAP028161, AGAP009165, AGAP009166 (IKK1 - IMD pathway signalling IKK-beta). (ird5orthologue immune response deficient 5)), AGAP009167, AGAP009168, AGAP009170, AGAP009172 (prolyl oligopeptidase), AGAP0091711 (tRNA-dihydrouridine synthase 3), AGAP009173 (fbp - fructose-1,6-biphosphatase), AGAP009174 (vacuolar protein sorting 41 homolog), AGAP009175 (galactosylxylosylprotein 3-beta-galactosyltransferase), AGAP0091761 (fatty acid synthase, animal type), AGAP0091771, AGAP0091781 (Reticulon 4 interacting protein 1), AGAP009179 (nucleolar protein 6), AGAP009180 (protein son of sevenless), AGAP009181, AGAP009182 (protein transport protein SEC61 subunit alpha).

The following 3 genes are within 50 kbp of the focal region: AGAP009160 (Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 1/2/3), AGAP009161 (deoxyribose-phosphate aldolase), AGAP0091624.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/CMS.UGS/3/1 XPEHH Cameroon An. gambiae 3R:28,240,000-28,380,000 1,234 100.0% nan
IHS/BFM/3/1 IHS Burkina Faso An. coluzzii 3R:28,260,000-28,620,000 1,058 100.0% Gste
IHS/GNS/3/1 IHS Guinea An. gambiae 3R:28,240,000-28,420,000 791 99.9% nan
XPEHH/CMS.GAS/3/2 XPEHH Cameroon An. gambiae 3R:28,260,000-28,320,000 232 100.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 92
    # data points      = 615
    # variables        = 4
    chi-square         = 207.191
    reduced chi-square = 0.339
    Akaike info crit   = -661.107
    Bayesian info crit = -643.421
[[Variables]]
    center:      0 (fixed)
    amplitude:   3.10430140 +/- 0.081979 (2.64%) (init= 3)
    decay:       2.50877389 +/- 0.158374 (6.31%) (init= 0.5)
    skew:       -0.99999999 +/- 0.011265 (1.13%) (init= 0)
    baseline:    1.74741223 +/- 0.053236 (3.05%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.733
    C(amplitude, baseline)       = -0.423
    C(decay, skew)               = -0.314
    C(skew, baseline)            =  0.267
    C(amplitude, skew)           = -0.199
    C(amplitude, decay)          = -0.113

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 614
    # variables        = 1
    chi-square         = 706.345
    reduced chi-square = 1.152
    Akaike info crit   = 88.026
    Bayesian info crit = 92.446
[[Variables]]
    c:   2.81962859 +/- 0.043319 (1.54%) (init= 1)

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