IHS/BFS/3/4

This page describes a signal of selection found in the Burkina Faso An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 20,800,000 and 20,920,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 3 genes overlap the focal region: AGAP008918 (STIP1 homology and U-box containing protein 1), AGAP028004, AGAP008919.

The following 6 genes are within 50 kbp of the focal region: AGAP008914, AGAP008915 (gamma-glutamyltranspeptidase), AGAP028196, AGAP008916 (RpL7 - 60S ribosomal protein L7), AGAP008917 (DNA topoisomerase II), AGAP028087.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 532
    # variables        = 4
    chi-square         = 76.657
    reduced chi-square = 0.145
    Akaike info crit   = -1022.645
    Bayesian info crit = -1005.538
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.69820110 +/- 0.121689 (7.17%) (init= 3)
    sigma:       0.21364417 +/- 0.019491 (9.12%) (init= 0.5)
    skew:        0.53569369 +/- 0.109842 (20.50%) (init= 0)
    baseline:    1.74616214 +/- 0.017192 (0.98%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.512
    C(sigma, skew)               = -0.340
    C(sigma, baseline)           = -0.151
    C(amplitude, baseline)       = -0.106

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 531
    # variables        = 1
    chi-square         = 112.183
    reduced chi-square = 0.212
    Akaike info crit   = -823.508
    Bayesian info crit = -819.233
[[Variables]]
    c:   1.80629060 +/- 0.019965 (1.11%) (init= 1)

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