IHS/CMS/2/3

This page describes a signal of selection found in the Cameroon An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 34,254,895 and 34,674,895. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 29 genes overlap the focal region: AGAP006579, AGAP006580 (parkin), AGAP006581 (Cysteine-rich venom protein), AGAP006582 (Cysteine-rich venom protein), AGAP006583 (Cysteine-rich venom protein), AGAP028458, AGAP006584 (Cysteine-rich venom protein), AGAP028459, AGAP006585 (Cysteine-rich venom protein), AGAP006586, AGAP006587 (Cysteine-rich venom protein), AGAP006588, AGAP028666, AGAP028665, AGAP006590 (T-lymphoma invasion and metastasis-inducing protein 1), AGAP006591, AGAP006592, AGAP006593 (dual specificity phosphatase), AGAP006594 (solute carrier family 17, member 5), AGAP006595 (solute carrier family 17 member 5), AGAP006596, AGAP0065974 (CPR72 - cuticular protein RR-2 family 72), AGAP006598, AGAP006599 (ATP-dependent RNA helicase A), AGAP006600, AGAP006601, AGAP006602, AGAP006603, AGAP006604 (U6 snRNA-associated Sm-like protein LSm5).

The following 11 genes are within 50 kbp of the focal region: AGAP006573 (integrin-linked kinase), AGAP006574, AGAP006575 (multifunctional methyltransferase subunit TRM112), AGAP0065761 (malate/L-lactate dehydrogenase), AGAP006577, AGAP006578, AGAP006605, AGAP006606, AGAP006607 (eIF3i - Eukaryotic translation initiation factor 3 subunit I), AGAP006608, AGAP006609.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 48
    # data points      = 516
    # variables        = 4
    chi-square         = 94.004
    reduced chi-square = 0.184
    Akaike info crit   = -870.628
    Bayesian info crit = -853.644
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.71788018 +/- 0.051966 (3.03%) (init= 3)
    sigma:       2.55830039 +/- 0.101293 (3.96%) (init= 0.5)
    skew:        0.93413080 +/- 0.038927 (4.17%) (init= 0)
    baseline:    1.77012715 +/- 0.036710 (2.07%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, baseline)       = -0.622
    C(sigma, baseline)           = -0.576
    C(sigma, skew)               = -0.256
    C(amplitude, skew)           = -0.161
    C(skew, baseline)            =  0.146

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 515
    # variables        = 1
    chi-square         = 295.333
    reduced chi-square = 0.575
    Akaike info crit   = -284.372
    Bayesian info crit = -280.128
[[Variables]]
    c:   2.54846505 +/- 0.033401 (1.31%) (init= 1)

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