IHS/CMS/3/2

This page describes a signal of selection found in the Cameroon An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 42,500,000 and 42,660,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP009768 (solute carrier family 6 (neurotransmitter transporter, GABA) member 1) overlaps the focal region.

The following 10 genes are within 50 kbp of the focal region: AGAP009757 (ANCE7 - angiotensin-converting enzyme 7), AGAP029049, AGAP029054 (NimB2 - nimrod B2), AGAP029055, AGAP009763, AGAP009764, AGAP009765 (dymeclin), AGAP009766, AGAP009769, AGAP009770 (GPRCAL1 - putative calcitonin receptor 1).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/BFS/3/7 IHS Burkina Faso An. gambiae 3R:42,540,000-42,980,000 141 96.4% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 58
    # data points      = 620
    # variables        = 4
    chi-square         = 75.817
    reduced chi-square = 0.123
    Akaike info crit   = -1294.868
    Bayesian info crit = -1277.149
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.60876542 +/- 0.039611 (6.51%) (init= 3)
    sigma:       2.99999904 +/- 0.249057 (8.30%) (init= 0.5)
    skew:       -0.94946405 +/- 0.083738 (8.82%) (init= 0)
    baseline:    1.75588485 +/- 0.030711 (1.75%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, baseline)       = -0.689
    C(sigma, baseline)           =  0.555
    C(amplitude, skew)           =  0.233
    C(skew, baseline)            = -0.137

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 619
    # variables        = 1
    chi-square         = 103.720
    reduced chi-square = 0.168
    Akaike info crit   = -1103.785
    Bayesian info crit = -1099.357
[[Variables]]
    c:   2.07745427 +/- 0.016466 (0.79%) (init= 1)

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