IHS/GAS/2/1

This page describes a signal of selection found in the Gabon An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 13,880,000 and 14,040,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 25 genes overlap the focal region: AGAP002009 (dynein heavy chain, axonemal), AGAP002010, AGAP002011 (ammonium transporter Rh), AGAP002012, AGAP012959, AGAP013169, AGAP013098, AGAP013325, AGAP013295, AGAP013531, AGAP013438, AGAP013072, AGAP013483, AGAP002013 (leucine-rich repeat-containing protein 49), AGAP002014 (leucyl-tRNA synthetase), AGAP002015 (dynein heavy chain 1, cytosolic), AGAP002016 (iron/zinc purple acid phosphatase-like protein precursor), AGAP002017 (Hexosyltransferase), AGAP002018 (histone-lysine N-methyltransferase setd3), AGAP013249, AGAP002019 (COMPASS component SWD3), AGAP002020 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8), AGAP002021 (lysophosphatidate acyltransferase), AGAP002022 (Protein maelstrom), AGAP013079.

The following 7 genes are within 50 kbp of the focal region: AGAP002008, AGAP002023, AGAP002024, AGAP002025 (OBP11 - odorant-binding protein 11), AGAP002026 (Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)), AGAP002028 (E3 ubiquitin-protein ligase RNF13), AGAP002030 (bromodomain and WD repeat domain containing protein 1/3).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 113
    # data points      = 635
    # variables        = 4
    chi-square         = 300.323
    reduced chi-square = 0.476
    Akaike info crit   = -467.468
    Bayesian info crit = -449.653
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.99285303 +/- 0.089953 (9.06%) (init= 3)
    sigma:       1.56883425 +/- 0.175104 (11.16%) (init= 0.5)
    skew:       -0.20047559 +/- 0.107214 (53.48%) (init= 0)
    baseline:    2.31709136 +/- 0.040571 (1.75%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, baseline)           = -0.541
    C(amplitude, sigma)          = -0.339
    C(amplitude, baseline)       = -0.285
    C(sigma, skew)               =  0.109

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 634
    # variables        = 1
    chi-square         = 357.188
    reduced chi-square = 0.564
    Akaike info crit   = -361.780
    Bayesian info crit = -357.328
[[Variables]]
    c:   2.55064351 +/- 0.029832 (1.17%) (init= 1)

Comments