IHS/GAS/3/1

This page describes a signal of selection found in the Gabon An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 44,140,000 and 44,300,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP009848, AGAP009849 (SP14D1).

The following 12 genes are within 50 kbp of the focal region: AGAP009840 (USO1 vesicle docking protein homolog), AGAP009841, AGAP009842 (ribonuclease T2), AGAP009843, AGAP009844 (CLIPB15 - CLIP-domain serine protease), AGAP009845, AGAP009846 (Ras-related protein Rab-9A), AGAP009847 (Outspread), AGAP009850 (ABCG7 - ATP-binding cassette transporter (ABC transporter) family G member 7), AGAP009851, AGAP009852 (mitochondrial fission 1 protein), AGAP0098533 (Gr5 - gustatory receptor 5).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/CMS.GAS/3/1 XPEHH Cameroon An. gambiae 3R:43,920,000-44,560,000 538 99.5% nan
XPEHH/AOM.BFM/3/1 XPEHH Angola An. coluzzii 3R:43,860,000-44,500,000 314 99.7% nan
IHS/AOM/3/1 IHS Angola An. coluzzii 3R:43,740,000-44,560,000 112 99.2% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 47
    # data points      = 468
    # variables        = 4
    chi-square         = 86.118
    reduced chi-square = 0.186
    Akaike info crit   = -784.208
    Bayesian info crit = -767.614
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.97748687 +/- 0.078093 (7.99%) (init= 3)
    decay:       1.04724593 +/- 0.207456 (19.81%) (init= 0.5)
    skew:        0.99999520 +/- 0.171506 (17.15%) (init= 0)
    baseline:    2.30342580 +/- 0.041091 (1.78%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.653
    C(decay, skew)               = -0.427
    C(amplitude, decay)          = -0.316
    C(amplitude, baseline)       = -0.229
    C(amplitude, skew)           =  0.196

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 467
    # variables        = 1
    chi-square         = 115.312
    reduced chi-square = 0.247
    Akaike info crit   = -651.188
    Bayesian info crit = -647.042
[[Variables]]
    c:   2.53428770 +/- 0.023018 (0.91%) (init= 1)

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