IHS/GAS/3/2

This page describes a signal of selection found in the Gabon An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 10,399,316 and 10,559,316. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 10 genes overlap the focal region: AGAP010790 (dynein heavy chain 2, cytosolic), AGAP010791 (polyribonucleotide nucleotidyltransferase), AGAP010792 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 9), AGAP010793 (synembryn-A), AGAP010794, AGAP010795, AGAP010796, AGAP010797, AGAP010798 (female reproductive tract protease), AGAP029080.

The following 9 genes are within 50 kbp of the focal region: AGAP010786, AGAP010787 (timeless), AGAP010788 (fatty acyl-CoA reductase 1), AGAP010789, AGAP010799, AGAP010800 (nuclear protein NHN1), AGAP010801 (phosphatidylinositol 4-kinase), AGAP010802, AGAP010803.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 63
    # data points      = 265
    # variables        = 4
    chi-square         = 49.356
    reduced chi-square = 0.189
    Akaike info crit   = -437.375
    Bayesian info crit = -423.056
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.95268047 +/- 0.094017 (9.87%) (init= 3)
    sigma:       3          +/- 0.000148 (0.00%) (init= 0.5)
    skew:       -0.35550336 +/- 0.108373 (30.48%) (init= 0)
    baseline:    2.45610149 +/- 0.085933 (3.50%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, baseline)           =  0.793
    C(amplitude, baseline)       = -0.746
    C(sigma, skew)               = -0.466
    C(amplitude, sigma)          = -0.410
    C(amplitude, skew)           =  0.176
    C(skew, baseline)            = -0.143

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 12
    # data points      = 264
    # variables        = 1
    chi-square         = 70.965
    reduced chi-square = 0.270
    Akaike info crit   = -344.835
    Bayesian info crit = -341.259
[[Variables]]
    c:   2.88731293 +/- 0.031969 (1.11%) (init= 1)

Comments