IHS/UGS/3/2

This page describes a signal of selection found in the Uganda An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 18,760,000 and 19,000,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 3 genes overlap the focal region: AGAP008824, AGAP008825, AGAP008826.

Gene AGAP028025 is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/BFS/3/5 IHS Burkina Faso An. gambiae 3R:18,760,000-18,920,000 297 90.4% nan
IHS/BFM/3/3 IHS Burkina Faso An. coluzzii 3R:18,600,000-19,000,000 215 96.1% nan
H12/UGS/3/4 H12 Uganda An. gambiae 3R:18,780,000-19,000,000 210 72.4% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 63
    # data points      = 552
    # variables        = 4
    chi-square         = 33.839
    reduced chi-square = 0.062
    Akaike info crit   = -1533.144
    Bayesian info crit = -1515.890
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.41775529 +/- 0.099896 (7.05%) (init= 3)
    sigma:       0.44167177 +/- 0.025113 (5.69%) (init= 0.5)
    skew:        0.34935962 +/- 0.048605 (13.91%) (init= 0)
    baseline:    1.71833559 +/- 0.011533 (0.67%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.766
    C(sigma, baseline)           = -0.238
    C(sigma, skew)               = -0.172

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 551
    # variables        = 1
    chi-square         = 61.550
    reduced chi-square = 0.112
    Akaike info crit   = -1205.731
    Bayesian info crit = -1201.419
[[Variables]]
    c:   1.79664053 +/- 0.014251 (0.79%) (init= 1)

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