XPEHH/AOM.BFM/2/1

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Burkina Faso An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 56,520,000 and 56,920,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 40 genes overlap the focal region: AGAP004453 (GPRDOP3 - GPCR Dopamine Family 3), AGAP004454, AGAP004455 (GNBPB1 - 3-glucan binding protein), AGAP004456 (GNBPB5 - 3-glucan binding protein), AGAP004457 (Sugar transporter ERD6-like 4), AGAP004458 (Leucine-rich repeat-containing protein 58), AGAP004459 (ubiquitin-like 1-activating enzyme E1 A), AGAP004460 (sialic acid synthase), AGAP004461 (solute carrier family 30 (zinc transporter), member 5/7), AGAP004462 (RpS25 - 40S ribosomal protein S25), AGAP004463 (ribosomal RNA-processing protein 17), AGAP004464, AGAP004465 (18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase), AGAP004466, AGAP004467 (centromere/kinetochore protein ZW10), AGAP004468 (Phosducin-like protein), AGAP004469 (phosphatidylinositol transfer protein, beta like), AGAP004470 (STE24 endopeptidase), AGAP004471, AGAP004472, AGAP004473, AGAP013052, AGAP004474, AGAP004475 (IR100i - ionotropic receptor IR100i), AGAP004476 (solute carrier family 18 (vesicular monoamine), member 2), AGAP004477 (Polyphosphoinositide phosphatase), AGAP004478 (ATP synthase subunit s, mitochondrial precursor), AGAP004479 (reduction in cnn dots 1), AGAP004480 (DNA-directed RNA polymerase III subunit RPC4), AGAP004481 (mRpS26 - 28S ribosomal protein S26, mitochondrial), AGAP004483 (Lethal giant larvae), AGAP004484 (CDGSH iron sulfur domain-containing protein 2 homolog), AGAP004485, AGAP004486 (adiponectin receptor), AGAP004487 (SNX5 protein), AGAP004488 (actin-related protein 5), AGAP004489, AGAP004490, AGAP004491 (exonuclease 1), AGAP004492 (upstream activation factor subunit UAF30).

No genes are within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 83
    # data points      = 395
    # variables        = 4
    chi-square         = 180.247
    reduced chi-square = 0.461
    Akaike info crit   = -301.901
    Bayesian info crit = -285.985
[[Variables]]
    center:      0 (fixed)
    amplitude:   2.07285347 +/- 0.087371 (4.22%) (init= 3)
    sigma:       2.47378308 +/- 0.158131 (6.39%) (init= 0.5)
    skew:       -0.99999540 +/- 0.068793 (6.88%) (init= 0)
    baseline:    2.22945297 +/- 0.058532 (2.63%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, baseline)       = -0.598
    C(sigma, baseline)           = -0.468
    C(amplitude, skew)           =  0.224
    C(sigma, skew)               = -0.144
    C(amplitude, sigma)          = -0.124
    C(skew, baseline)            = -0.119

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 12
    # data points      = 394
    # variables        = 1
    chi-square         = 448.223
    reduced chi-square = 1.141
    Akaike info crit   = 52.802
    Bayesian info crit = 56.779
[[Variables]]
    c:   3.13284006 +/- 0.053802 (1.72%) (init= 1)

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