XPEHH/AOM.BFM/2/6

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Burkina Faso An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 48,280,000 and 48,360,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP004039 (afadin) overlaps the focal region.

The following 4 genes are within 50 kbp of the focal region: AGAP013324 (putative G-protein coupled receptor GPCR), AGAP004035 (GPRFSH - putative glyco-protein hormone fsh-like receptor), AGAP0040361 (HPX7 - heme peroxidase 7), AGAP0040381 (HPX8 - heme peroxidase 8).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 63
    # data points      = 481
    # variables        = 4
    chi-square         = 115.201
    reduced chi-square = 0.242
    Akaike info crit   = -679.442
    Bayesian info crit = -662.738
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.82161126 +/- 0.156707 (8.60%) (init= 3)
    sigma:       0.19121515 +/- 0.021848 (11.43%) (init= 0.5)
    skew:        0.87263898 +/- 0.138672 (15.89%) (init= 0)
    baseline:    1.91848492 +/- 0.023426 (1.22%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.501
    C(sigma, skew)               = -0.396
    C(sigma, baseline)           = -0.153
    C(amplitude, baseline)       = -0.110

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 480
    # variables        = 1
    chi-square         = 157.483
    reduced chi-square = 0.329
    Akaike info crit   = -532.945
    Bayesian info crit = -528.771
[[Variables]]
    c:   1.99157979 +/- 0.026171 (1.31%) (init= 1)

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