XPEHH/AOM.GWA/3/1

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Guinea Bissau population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 44,320,000 and 44,480,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 9 genes overlap the focal region: AGAP009850 (ABCG7 - ATP-binding cassette transporter (ABC transporter) family G member 7), AGAP009851, AGAP009852 (mitochondrial fission 1 protein), AGAP0098533 (Gr5 - gustatory receptor 5), AGAP0098543 (Gr6 - gustatory receptor 6), AGAP0098553 (Gr7 - gustatory receptor 7), AGAP0098563 (Gr8 - gustatory receptor 8), AGAP0098573 (Gr4 - gustatory receptor 4), AGAP0098583 (Gr3 - gustatory receptor 3).

The following 2 genes are within 50 kbp of the focal region: AGAP009859, AGAP009860.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/CMS.GAS/3/1 XPEHH Cameroon An. gambiae 3R:43,920,000-44,560,000 538 99.5% nan
XPEHH/AOM.BFM/3/1 XPEHH Angola An. coluzzii 3R:43,860,000-44,500,000 314 99.7% nan
H12/UGS/3/3 H12 Uganda An. gambiae 3R:44,380,000-45,140,000 292 95.0% nan
IHS/AOM/3/1 IHS Angola An. coluzzii 3R:43,740,000-44,560,000 112 99.2% nan
XPEHH/UGS.BFS/3/6 XPEHH Uganda An. gambiae 3R:44,440,000-44,520,000 95 99.7% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 62
    # data points      = 578
    # variables        = 4
    chi-square         = 258.921
    reduced chi-square = 0.451
    Akaike info crit   = -456.163
    Bayesian info crit = -438.724
[[Variables]]
    center:      0 (fixed)
    amplitude:   2.07906503 +/- 0.130839 (6.29%) (init= 3)
    decay:       0.82130914 +/- 0.123782 (15.07%) (init= 0.5)
    skew:        0.99999999 +/- 0.041898 (4.19%) (init= 0)
    baseline:    2.61615870 +/- 0.042094 (1.61%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.529
    C(decay, skew)               = -0.528
    C(amplitude, decay)          = -0.450

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 577
    # variables        = 1
    chi-square         = 404.691
    reduced chi-square = 0.703
    Akaike info crit   = -202.673
    Bayesian info crit = -198.315
[[Variables]]
    c:   2.92857854 +/- 0.034893 (1.19%) (init= 1)

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