XPEHH/AOM.GWA/X/1

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Guinea Bissau population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 4,340,000 and 4,380,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP000232 (regulator of G-protein signaling), AGAP000233.

The following 6 genes are within 50 kbp of the focal region: AGAP000228 (netrin 1), AGAP0002303 (Or52 - odorant receptor 52), AGAP0129752 (histamine-gated chloride channel subunit), AGAP000234, AGAP013530, AGAP000235 (Thymosin).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/AOM/X/1 H12 Angola An. coluzzii X:4,340,000-4,380,000 519 97.8% nan
XPEHH/AOM.BFM/X/1 XPEHH Angola An. coluzzii X:4,320,000-4,360,000 292 99.9% nan
IHS/AOM/X/1 IHS Angola An. coluzzii X:4,280,000-4,360,000 178 99.9% nan
XPEHH/AOM.GAS/X/1 XPEHH Angola An. coluzzii X:4,340,000-4,420,000 137 100.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 199
    # variables        = 4
    chi-square         = 53.109
    reduced chi-square = 0.272
    Akaike info crit   = -254.871
    Bayesian info crit = -241.698
[[Variables]]
    center:      0 (fixed)
    amplitude:   4.63437683 +/- 0.269851 (5.82%) (init= 3)
    decay:       0.18003958 +/- 0.017274 (9.59%) (init= 0.5)
    skew:        0.33907474 +/- 0.092900 (27.40%) (init= 0)
    baseline:    2.15569878 +/- 0.041484 (1.92%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.664
    C(decay, baseline)           = -0.292

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 198
    # variables        = 1
    chi-square         = 184.493
    reduced chi-square = 0.937
    Akaike info crit   = -11.989
    Bayesian info crit = -8.701
[[Variables]]
    c:   2.46885087 +/- 0.068773 (2.79%) (init= 1)

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