XPEHH/BFM.BFS/2/5

This page describes a signal of selection found in the Burkina Faso An. coluzzii population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 28,200,000 and 28,240,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 10 genes overlap the focal region: AGAP002836 (endoribonuclease Dicer), AGAP002837, AGAP013054, AGAP002838, AGAP013404, AGAP002839 (WD repeat-containing protein 85), AGAP002840, AGAP013351, AGAP002841 (pyridoxal phosphate phosphatase PHOSPHO2), AGAP002842 (CLIPD1 protein).

The following 2 genes are within 50 kbp of the focal region: AGAP002835 (alpha-tocopherol transfer protein-like protein), AGAP002845.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/CMS/2/1 IHS Cameroon An. gambiae 2R:28,240,000-28,560,000 1,249 100.0% Cyp6p
XPEHH/UGS.BFS/2/1 XPEHH Uganda An. gambiae 2R:27,980,000-28,280,000 753 99.9% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 47
    # data points      = 741
    # variables        = 4
    chi-square         = 368.646
    reduced chi-square = 0.500
    Akaike info crit   = -509.339
    Bayesian info crit = -490.907
[[Variables]]
    center:      0 (fixed)
    amplitude:   2.15973926 +/- 0.197464 (9.14%) (init= 3)
    sigma:       0.15000000 +/- 0.001384 (0.92%) (init= 0.5)
    skew:        0.99999862 +/- 0.110442 (11.04%) (init= 0)
    baseline:    2.57643528 +/- 0.027023 (1.05%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, skew)               =  0.498
    C(amplitude, sigma)          =  0.495
    C(sigma, baseline)           =  0.135
    C(amplitude, baseline)       = -0.100

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 740
    # variables        = 1
    chi-square         = 447.941
    reduced chi-square = 0.606
    Akaike info crit   = -369.471
    Bayesian info crit = -364.865
[[Variables]]
    c:   2.65349952 +/- 0.028619 (1.08%) (init= 1)

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