XPEHH/BFM.BFS/3/1

This page describes a signal of selection found in the Burkina Faso An. coluzzii population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 11,579,316 and 11,659,316. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 4 genes overlap the focal region: AGAP010830 (TEP9 - thioester-containing protein 9), AGAP010831 (TEP8 - thioester-containing protein 8), AGAP010832 (TEP19 - thioester-containing protein 19), AGAP010833 (CLIPB14 - CLIP-domain serine protease).

Gene AGAP010829 (CASPS12 - short caspase 12) is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/BFM.GWA/3/2 XPEHH Burkina Faso An. coluzzii 3L:11,599,316-11,659,316 230 100.0% nan
H12/BFM/3/4 H12 Burkina Faso An. coluzzii 3L:11,619,316-11,659,316 95 99.6% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 68
    # data points      = 347
    # variables        = 4
    chi-square         = 467.072
    reduced chi-square = 1.362
    Akaike info crit   = 111.114
    Bayesian info crit = 126.512
[[Variables]]
    center:      0 (fixed)
    amplitude:   6.27341862 +/- 0.414322 (6.60%) (init= 3)
    decay:       0.51197305 +/- 0.056930 (11.12%) (init= 0.5)
    skew:        1          +/- 0.048914 (4.89%) (init= 0)
    baseline:    2.86043029 +/- 0.073744 (2.58%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.669
    C(decay, baseline)           = -0.335
    C(decay, skew)               = -0.207

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 12
    # data points      = 346
    # variables        = 1
    chi-square         = 982.397
    reduced chi-square = 2.848
    Akaike info crit   = 363.071
    Bayesian info crit = 366.917
[[Variables]]
    c:   3.45719578 +/- 0.090718 (2.62%) (init= 1)

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