XPEHH/BFM.BFS/3/2

This page describes a signal of selection found in the Burkina Faso An. coluzzii population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 33,259,316 and 33,299,316. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 11 genes overlap the focal region: AGAP011785 (CLIPE6 - CLIP-domain serine protease), AGAP011786 (CLIPE7 - CLIP-domain serine protease), AGAP011787 (CLIPA5 - CLIP-domain serine protease), AGAP011788 (CLIPA14 - CLIP-domain serine protease), AGAP011789 (CLIPA6 - CLIP-domain serine protease), AGAP011790 (CLIPA2 - CLIP-domain serine protease), AGAP011791 (CLIPA1 - CLIP-domain serine protease), AGAP028725 (SPCLIP1 - CLIP-domain serine protease), AGAP011792 (CLIPA7 - CLIP-domain serine protease), AGAP011793 (CLIP-domain serine protease), AGAP011794 (CLIPA1 protein).

The following 17 genes are within 50 kbp of the focal region: AGAP011779, AGAP011780 (CLIPA4 - CLIP-domain serine protease), AGAP011781 (CLIPA12 - CLIP-domain serine protease), AGAP011782 (CLIPE2 - CLIP-domain serine protease), AGAP011783 (CLIPA13 - CLIP-domain serine protease), AGAP011784, AGAP011795, AGAP011796 (solute carrier family 29 (equilibrative nucleoside transporter), member 4), AGAP011797, AGAP0117981 (acyl-CoA oxidase), AGAP011799 (Anaphase-promoting complex subunit 10), AGAP011800 (Transaldolase), AGAP011801 (Coiled-coil domain-containing protein 22 homolog), AGAP011802 (RpL39 - 60S ribosomal protein L39), AGAP011803 (mRpS27 - 28S ribosomal protein S27, mitochondrial), AGAP011804 (translation initiation factor 2D), AGAP011805 (ornithine decarboxylase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 81
    # data points      = 555
    # variables        = 4
    chi-square         = 314.314
    reduced chi-square = 0.570
    Akaike info crit   = -307.559
    Bayesian info crit = -290.283
[[Variables]]
    center:      0 (fixed)
    amplitude:   5.15347559 +/- 0.404434 (7.85%) (init= 3)
    decay:       0.15000001 +/- 0.038109 (25.41%) (init= 0.5)
    skew:       -0.36209189 +/- 0.126254 (34.87%) (init= 0)
    baseline:    1.79208015 +/- 0.033439 (1.87%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          =  0.678
    C(decay, skew)               = -0.253
    C(decay, baseline)           =  0.187

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 554
    # variables        = 1
    chi-square         = 406.635
    reduced chi-square = 0.735
    Akaike info crit   = -169.323
    Bayesian info crit = -165.006
[[Variables]]
    c:   1.89620847 +/- 0.036432 (1.92%) (init= 1)

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