XPEHH/CMS.GAS/2/1

This page describes a signal of selection found in the Cameroon An. gambiae population when compared with the Gabon An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 45,374,895 and 45,454,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP007326, AGAP007327 (E74-like factor 1/2/4).

The following 9 genes are within 50 kbp of the focal region: AGAP007317, AGAP007318, AGAP007319, AGAP007320, AGAP007321, AGAP007322, AGAP007323, AGAP007324, AGAP007325.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 78
    # data points      = 783
    # variables        = 4
    chi-square         = 166.403
    reduced chi-square = 0.214
    Akaike info crit   = -1204.647
    Bayesian info crit = -1185.994
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.78192699 +/- 0.045636 (5.84%) (init= 3)
    sigma:       2.50903586 +/- 0.199956 (7.97%) (init= 0.5)
    skew:       -0.97418369 +/- 0.079434 (8.15%) (init= 0)
    baseline:    1.23808627 +/- 0.035658 (2.88%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, baseline)       = -0.710
    C(sigma, baseline)           = -0.589
    C(sigma, skew)               =  0.306
    C(amplitude, skew)           =  0.188
    C(skew, baseline)            = -0.168
    C(amplitude, sigma)          =  0.105

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 782
    # variables        = 1
    chi-square         = 230.297
    reduced chi-square = 0.295
    Akaike info crit   = -953.982
    Bayesian info crit = -949.321
[[Variables]]
    c:   1.64947086 +/- 0.019418 (1.18%) (init= 1)

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