XPEHH/CMS.UGS/3/2

This page describes a signal of selection found in the Cameroon An. gambiae population when compared with the Uganda An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 26,939,316 and 26,979,316. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 5 genes overlap the focal region: AGAP011538, AGAP011539 (dynein intermediate chain 2, axonemal), AGAP011540 (dynein intermediate chain 2, axonemal), AGAP011541 (Ecto-NOX disulfide-thiol exchanger 1), AGAP011542.

The following 7 genes are within 50 kbp of the focal region: AGAP011533 (tetratricopeptide repeat protein 15), AGAP011534, AGAP011535 (transcription elongation factor B, polypeptide 1), AGAP011536 (Mini-chromosome maintenance complex-binding protein), AGAP011537 (Argonaute 3), AGAP028430, AGAP011543.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/BFS/3/2 H12 Burkina Faso An. gambiae 3L:26,879,316-26,979,316 291 92.7% nan
H12/GNS/3/3 H12 Guinea An. gambiae 3L:26,939,316-26,979,316 229 94.4% nan
IHS/BFS/3/6 IHS Burkina Faso An. gambiae 3L:26,919,316-26,959,316 187 96.6% nan
IHS/CMS/3/3 IHS Cameroon An. gambiae 3L:26,919,316-26,959,316 186 93.0% nan
IHS/GNS/3/3 IHS Guinea An. gambiae 3L:26,919,316-26,959,316 115 96.8% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 56
    # data points      = 786
    # variables        = 4
    chi-square         = 217.339
    reduced chi-square = 0.278
    Akaike info crit   = -1002.400
    Bayesian info crit = -983.733
[[Variables]]
    center:      0 (fixed)
    amplitude:   4.81273524 +/- 0.284381 (5.91%) (init= 3)
    decay:       0.15000000 +/- 0.001414 (0.94%) (init= 0.5)
    skew:        0.47543136 +/- 0.089213 (18.76%) (init= 0)
    baseline:    1.98858246 +/- 0.019561 (0.98%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.647
    C(decay, skew)               = -0.312
    C(decay, baseline)           = -0.197
    C(amplitude, skew)           =  0.115

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 785
    # variables        = 1
    chi-square         = 301.278
    reduced chi-square = 0.384
    Akaike info crit   = -749.755
    Bayesian info crit = -745.089
[[Variables]]
    c:   2.05907978 +/- 0.022125 (1.07%) (init= 1)

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