XPEHH/GAS.BFS/2/1

This page describes a signal of selection found in the Gabon An. gambiae population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 15,294,895 and 15,694,895. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 35 genes overlap the focal region: AGAP005412, AGAP005413 (survival of motor neuron protein-interacting protein 1), AGAP005414 (misexpression suppressor of ras 6), AGAP005415 (FtsJ methyltransferase domain-containing protein 1), AGAP005416 (DEF4 - defensin anti-microbial peptide), AGAP005417 (protein singed wings 2), AGAP005418 (aminoacyl tRNA synthase complex-interacting multifunctional protein 2), AGAP0054191 (Adrenodoxin_red - NADPH:adrenodoxin oxidoreductase, mitochondrial), AGAP005420, AGAP005421 (mitochondrial inner membrane protein OXA1L), AGAP005422, AGAP005423 (Prosalpha4 - 26S proteasome alpha 4 subunit), AGAP005424, AGAP013197, AGAP005425 (actin-binding LIM protein), AGAP005427 (RpL28 - 60S ribosomal protein L28), AGAP005428 (transcription elongation factor SPT4 1), AGAP005429 (Thoc6 - THO complex subunit 6), AGAP005430, AGAP005431 (thioredoxin domain-containing protein), AGAP005432 (programmed cell death protein 5), AGAP005433, AGAP005434 (vitellogenic carboxypeptidase-like protein), AGAP028445, AGAP0054351 (Iodotyrosine dehalogenase), AGAP005437, AGAP005438 (ribosome biogenesis protein MAK21), AGAP005440, AGAP005444, AGAP005445 (Ras-related C3 botulinum toxin substrate), AGAP005446, AGAP0054471 (trimethyllysine dioxygenase), AGAP005448 (B9 domain-containing protein 2), AGAP005449 (E3 ubiquitin-protein ligase CBL), AGAP005450.

The following 6 genes are within 50 kbp of the focal region: AGAP005411, AGAP028446, AGAP0054514 (CPR11 - cuticular protein RR-1 family 11), AGAP0054534 (CPR12 - cuticular protein RR-1 family 12), AGAP0054544 (CPR13 - cuticular protein RR-1 family 13), AGAP0054554 (CPR14 - cuticular protein RR-1 family 14).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/GAS.GWA/2/3 XPEHH Gabon An. gambiae 2L:15,254,895-15,554,895 183 95.6% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 53
    # data points      = 595
    # variables        = 4
    chi-square         = 118.507
    reduced chi-square = 0.201
    Akaike info crit   = -952.083
    Bayesian info crit = -934.529
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.63390621 +/- 0.081555 (4.99%) (init= 3)
    decay:       2.99999979 +/- 0.419335 (13.98%) (init= 0.5)
    skew:       -0.24167579 +/- 0.056810 (23.51%) (init= 0)
    baseline:    1.32133338 +/- 0.089834 (6.80%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.912
    C(amplitude, baseline)       = -0.773
    C(amplitude, decay)          =  0.517
    C(decay, skew)               =  0.126

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 594
    # variables        = 1
    chi-square         = 226.183
    reduced chi-square = 0.381
    Akaike info crit   = -571.527
    Bayesian info crit = -567.140
[[Variables]]
    c:   2.05338641 +/- 0.025340 (1.23%) (init= 1)

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