XPEHH/GWA.BFM/3/1

This page describes a signal of selection found in the Guinea Bissau population when compared with the Burkina Faso An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 6,100,000 and 6,140,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 8 genes overlap the focal region: AGAP013769, AGAP008139, AGAP013729, AGAP008140, AGAP008141 (argininosuccinate lyase), AGAP008142, AGAP0081431, AGAP008144.

The following 9 genes are within 50 kbp of the focal region: AGAP008136 (peptidyl-prolyl cis-trans isomerase-like 4), AGAP008137 (Niemann-Pick C1 protein), AGAP008138, AGAP013752, AGAP013711, AGAP008146, AGAP028548, AGAP028549, AGAP008147 (tRNA-splicing ligase RtcB homolog).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 75
    # data points      = 764
    # variables        = 4
    chi-square         = 191.593
    reduced chi-square = 0.252
    Akaike info crit   = -1048.761
    Bayesian info crit = -1030.207
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.78919282 +/- 0.123376 (6.90%) (init= 3)
    sigma:       0.24069686 +/- 0.023294 (9.68%) (init= 0.5)
    skew:       -0.99999615 +/- 0.119971 (12.00%) (init= 0)
    baseline:    1.43556409 +/- 0.019147 (1.33%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, skew)               =  0.520
    C(amplitude, sigma)          = -0.466
    C(sigma, baseline)           = -0.163
    C(amplitude, baseline)       = -0.105

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 763
    # variables        = 1
    chi-square         = 237.806
    reduced chi-square = 0.312
    Akaike info crit   = -887.508
    Bayesian info crit = -882.871
[[Variables]]
    c:   1.51199880 +/- 0.020224 (1.34%) (init= 1)

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