XPEHH/UGS.CMS/3/4

This page describes a signal of selection found in the Uganda An. gambiae population when compared with the Cameroon An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3L between positions 16,319,316 and 16,359,316. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 6 genes overlap the focal region: AGAP011080 (hydroxymethylbilane synthase), AGAP011081 (Protein anon-73B1), AGAP011082 (heat shock transcription factor, invertebrate), AGAP011083, AGAP011084 (ATP-dependent RNA helicase DDX27), AGAP011085.

The following 19 genes are within 50 kbp of the focal region: AGAP028506, AGAP011072, AGAP028507, AGAP011073, AGAP028508, AGAP028509, AGAP011074, AGAP028686, AGAP028685, AGAP028687, AGAP028688, AGAP028689, AGAP028690, AGAP011076 (ubiquitin-conjugating enzyme E2 I), AGAP011077 (RpS12 - 40S ribosomal protein S12), AGAP011078 (zinc finger MYND domain-containing protein 10), AGAP011079, AGAP011086, AGAP028510.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/UGS.BFS/3/3 XPEHH Uganda An. gambiae 3L:16,319,316-16,359,316 138 100.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 75
    # data points      = 593
    # variables        = 4
    chi-square         = 1106.567
    reduced chi-square = 1.879
    Akaike info crit   = 377.927
    Bayesian info crit = 395.468
[[Variables]]
    center:      0 (fixed)
    amplitude:   7.07442801 +/- 0.621190 (8.78%) (init= 3)
    decay:       0.15000000 +/- 0.006246 (4.16%) (init= 0.5)
    skew:        0.61094771 +/- 0.173079 (28.33%) (init= 0)
    baseline:    2.94167092 +/- 0.058459 (1.99%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          =  0.678
    C(decay, baseline)           =  0.179
    C(amplitude, skew)           = -0.126

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 592
    # variables        = 1
    chi-square         = 1437.808
    reduced chi-square = 2.433
    Akaike info crit   = 527.322
    Bayesian info crit = 531.706
[[Variables]]
    c:   3.10652848 +/- 0.064102 (2.06%) (init= 1)

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